, Patiala, India.
Public Health Foundation of India, Indian Institute of Public Health, Delhi, India.
Biol Trace Elem Res. 2019 Apr;188(2):239-244. doi: 10.1007/s12011-018-1411-1. Epub 2018 Jun 16.
Indigenous preparations (IPs) have evoked a considerable interest in alleviating infections and chronic diseases and improving wellbeing. While such formulations have been a part of traditional practice in several countries and many have been reviewed scientifically for their claims, several of them until date remain to be investigated. A class of IPs for sex selection by Indian pregnant women exists with an aim of begetting a male offspring. In view of the leads obtained from our previous studies on detrimental effects of the newborn, for instance stillbirths and congenital malformations, we attempted to investigate the samples for heavy metal toxicity. Three samples were chosen following phytochemical analysis and reproductive toxicity of such preparations under in vivo conditions. The selected samples were examined for heavy metals-lead, cadmium, arsenic, and mercury using Microwave-assisted atomic absorption spectroscopy. The upper limit level of lead, mercury, and cadmium was found to be 18.56, 0.11, and 0.84 mg/kg respectively whereas arsenic was not detected. The levels of lead and mercury were found to be manifolds high in the IP samples that were primarily contributed by its constituents. The results of our study indicate the potential risk conferred upon, to both the mother and fetus on account of high levels of lead, mercury, and cadmium.
土著制剂（IPs）在缓解感染和慢性疾病以及提高幸福感方面引起了相当大的兴趣。虽然这些制剂是几个国家传统实践的一部分，并且许多制剂已经根据其声称进行了科学审查，但其中一些制剂直到现在仍有待研究。印度孕妇为选择性别而使用的一类 IPs 制剂旨在生育男性后代。鉴于我们之前关于新生儿有害影响的研究结果，例如死产和先天性畸形，我们试图调查这些样本是否存在重金属毒性。在体内条件下进行植物化学分析和生殖毒性研究后，选择了三个样本。使用微波辅助原子吸收光谱法对选定的样本进行了重金属（铅、镉、砷和汞）检测。结果发现，铅、汞和镉的上限水平分别为 18.56、0.11 和 0.84mg/kg，而未检测到砷。土著制剂样本中的铅和汞含量非常高，主要是由其成分造成的。我们的研究结果表明，由于铅、汞和镉含量高，对母亲和胎儿都存在潜在风险。
