Turku PET Centre, Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland; Turku PET Centre, University of Turku, Kiinamyllynkatu 4-8, 20520 Turku, Finland.
Department of Medical Physics, Faculty of Medicine, Kagawa University, Takamatsu, Kagawa, Japan.
Cell Metab. 2018 Aug 7;28(2):207-216.e3. doi: 10.1016/j.cmet.2018.05.020. Epub 2018 Jun 14.
Human studies suggest that a meal elevates glucose uptake in brown adipose tissue (BAT). However, in postprandial state the thermogenic activity and the metabolism of non-esterified fatty acids (NEFAs) in BAT remain unclear. Using indirect calorimetry combined with positron emission tomography and computed tomography (PET/CT), we showed that whole-body and BAT thermogenesis (oxygen consumption) increases after the ingestion of a mixed carbohydrate-rich meal, to the same extent as in cold stress. Postprandial NEFA uptake into BAT is minimal, possibly due to elevated plasma insulin inhibiting lipolysis. However, the variation in postprandial NEFA uptake is linked to BAT thermogenesis. We identified several genes participating in lipid metabolism to be expressed at higher levels in BAT compared with white fat in postprandial state, and to be positively correlated with BAT UCP1 expression. These findings suggest that substrates preferred by BAT in postprandial state are glucose or LPL-released NEFAs due to insulin stimulation.
人体研究表明，进食会提高棕色脂肪组织（BAT）中的葡萄糖摄取量。然而，在餐后状态下，BAT 的产热活性和非酯化脂肪酸（NEFA）代谢仍不清楚。本研究采用间接量热法结合正电子发射断层扫描和计算机断层扫描（PET/CT），结果显示，在摄入富含混合碳水化合物的餐后，全身和 BAT 的产热（耗氧量）与冷应激时相同程度地增加。餐后 BAT 摄取的 NEFA 很少，这可能是由于血浆胰岛素升高抑制了脂肪分解。然而，餐后 NEFA 摄取的变化与 BAT 的产热有关。我们发现，与白色脂肪组织相比，在餐后状态下，参与脂肪代谢的几个基因在 BAT 中的表达水平更高，并且与 BAT 解偶联蛋白 1（UCP1）的表达呈正相关。这些发现表明，BAT 在餐后更喜欢葡萄糖或 LPL 释放的 NEFA，这是由于胰岛素的刺激。
