Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing 400038, China; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Key Laboratory for Biomedical Photonics of Ministry of Education, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan 430074, China.
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Key Laboratory for Biomedical Photonics of Ministry of Education, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan 430074, China.
Neuron. 2018 Jul 11;99(1):47-55.e4. doi: 10.1016/j.neuron.2018.05.021. Epub 2018 Jun 14.
The ability to remember and to navigate to safe places is necessary for survival. Place navigation is known to involve medial entorhinal cortex (MEC)-hippocampal connections. However, learning-dependent changes in neuronal activity in the distinct circuits remain unknown. Here, by using optic fiber photometry in freely behaving mice, we discovered the experience-dependent induction of a persistent-task-associated (PTA) activity. This PTA activity critically depends on learned visual cues and builds up selectively in the MEC layer II-dentate gyrus, but not in the MEC layer III-CA1 pathway, and its optogenetic suppression disrupts navigation to the target location. The findings suggest that the visual system, the MEC layer II, and the dentate gyrus are essential hubs of a memory circuit for visually guided navigation.
记忆和找到安全地点的能力是生存所必需的。众所周知，位置导航涉及内侧嗅皮层（MEC）-海马连接。然而，不同回路中神经元活动的学习依赖性变化仍然未知。在这里，通过在自由活动的小鼠中使用光纤光度测定法，我们发现了持久任务相关（PTA）活动的经验依赖性诱导。这种 PTA 活动严重依赖于学习的视觉线索，并选择性地在 MEC 层 II-齿状回中建立，而不在 MEC 层 III-CA1 通路中建立，其光遗传抑制会破坏对目标位置的导航。这些发现表明，视觉系统、MEC 层 II 和齿状回是用于视觉引导导航的记忆回路的重要枢纽。
