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豚鼠胰腺腺泡中阿米洛利敏感的Na+/H+逆向转运体。其特性及蛙皮素的刺激作用

The amiloride sensitive Na+/H+ antiport in guinea pig pancreatic acini. Characterization and stimulation by caerulein.

作者信息

Dufresne M, Bastie M J, Vaysse N, Creach Y, Hollande E, Ribet A

出版信息

FEBS Lett. 1985 Jul 22;187(1):126-30. doi: 10.1016/0014-5793(85)81227-8.

DOI:10.1016/0014-5793(85)81227-8
PMID:2991002
Abstract

Amiloride and analogs decrease the initial rate of 22Na+ uptake by dispersed acini from guinea pig pancreas in a dose-dependent manner. The initial rate of amiloride-sensitive 22Na+ uptake depends on external Na+ and H+ concentrations and on internal pH. These results provide evidence for the existence of a Na+/H+ antiport in pancreatic acinar cells. Caerulein, a cholecystokinin analog, stimulates the activity of the Na+/H+ antiport.

摘要

阿米洛利及其类似物以剂量依赖性方式降低豚鼠胰腺分散腺泡对22Na+的初始摄取速率。阿米洛利敏感的22Na+摄取初始速率取决于细胞外Na+和H+浓度以及细胞内pH值。这些结果为胰腺腺泡细胞中存在Na+/H+反向转运体提供了证据。蛙皮素，一种胆囊收缩素类似物，可刺激Na+/H+反向转运体的活性。

相似文献

1
The amiloride sensitive Na+/H+ antiport in guinea pig pancreatic acini. Characterization and stimulation by caerulein.豚鼠胰腺腺泡中阿米洛利敏感的Na+/H+逆向转运体。其特性及蛙皮素的刺激作用
FEBS Lett. 1985 Jul 22;187(1):126-30. doi: 10.1016/0014-5793(85)81227-8.
2
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Biochemical characterization of the amiloride-sensitive Na+/H+ antiport in Chinese hamster lung fibroblasts.中国仓鼠肺成纤维细胞中阿米洛利敏感型Na+/H+逆向转运体的生化特性
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引用本文的文献

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Agonist-specific regulation of [Na+]i in pancreatic acinar cells.胰腺腺泡细胞中[Na⁺]i的激动剂特异性调节。
J Gen Physiol. 1995 Dec;106(6):1243-63. doi: 10.1085/jgp.106.6.1243.
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Na+, K+, and Cl- transport in resting pancreatic acinar cells.静息胰腺腺泡细胞中的钠、钾和氯离子转运
J Gen Physiol. 1995 Dec;106(6):1225-42. doi: 10.1085/jgp.106.6.1225.
3
CCK-related peptides stimulation of the Na+/H+ antiport in pancreatic acinar cells leads to cytoplasmic alkalinisation.胆囊收缩素相关肽刺激胰腺腺泡细胞中的钠/氢反向转运体导致细胞质碱化。
Gut. 1987;28 Suppl(Suppl):85-8. doi: 10.1136/gut.28.suppl.85.
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Acetylcholine-induced Na+ influx in the mouse lacrimal gland acinar cells: demonstration of multiple Na+ transport mechanisms by intracellular Na+ activity measurements.乙酰胆碱诱导的小鼠泪腺腺泡细胞中钠离子内流：通过细胞内钠离子活性测量证明多种钠离子转运机制
J Membr Biol. 1987;98(2):135-44. doi: 10.1007/BF01872126.
5
Mechanisms of regulation of the Na+/H+ exchanger.钠氢交换体的调节机制
J Membr Biol. 1986;90(1):1-12. doi: 10.1007/BF01869680.
6
Effects of intra- and extracellular H+ and Na+ concentrations on Na(+)-H+ antiport activity in the lacrimal gland acinar cells.细胞内和细胞外H⁺及Na⁺浓度对泪腺腺泡细胞中Na⁺-H⁺逆向转运活性的影响。
Pflugers Arch. 1990 Dec;417(4):382-90. doi: 10.1007/BF00370657.
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Int J Pancreatol. 1991 Sep;10(1):81-95. doi: 10.1007/BF02924256.