Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Am J Gastroenterol. 2018 Sep;113(9):1301. doi: 10.1038/s41395-018-0146-0. Epub 2018 Jun 18.
Over the course of the last 2 decades our knowledge of autoimmune pancreatitis has increased exponentially. In this review, we summarize the clinical presentation, diagnosis and treatment of AIP, to better allow general gastroenterologists and primary care providers to consider AIP as a as a rare but important cause of painless obstructive jaundice and recurrent acute pancreatitis. While steroids remain the mainstay of first line therapy, a number of patients with type 1 AIP require immunomodulators or rituximab to maintain remission; recommendations on the management of relapses continue to evolve.
在过去的 20 年中，我们对自身免疫性胰腺炎的认识呈指数级增长。在这篇综述中，我们总结了 AIP 的临床表现、诊断和治疗，以便更好地让普通胃肠病学家和初级保健提供者将 AIP 视为无痛性梗阻性黄疸和复发性急性胰腺炎的一个罕见但重要的原因。虽然类固醇仍然是一线治疗的主要方法，但许多 1 型 AIP 患者需要免疫调节剂或利妥昔单抗来维持缓解；关于复发管理的建议仍在不断发展。
