Enantioselective fluorination of α-branched aldehydes and subsequent conversion to α-hydroxyacetals stereospecific C-F bond cleavage.

The highly enantioselective fluorination of α-branched aldehydes was achieved using newly developed chiral primary amine catalyst . Furthermore, the C-F bond cleavage of the resulting α-fluoroaldehydes proceeded smoothly under alcoholic alkaline conditions to yield the corresponding α-hydroxyacetals in a stereospecific manner. Accordingly, the one-pot conversion of α-branched aldehydes into α-hydroxyacetals was achieved for the first time in high enantioselectivity.