Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
J Infect Dis. 2018 Sep 22;218(9):1474-1479. doi: 10.1093/infdis/jiy356.
We examined associations of 5 plasma choline metabolites with carotid plaque among 520 HIV-infected and 217 HIV-uninfected participants (112 incident plaque cases) over 7 years. After multivariable adjustment, higher gut microbiota-related metabolite trimethylamine-N-oxide (TMAO) was associated with an increased risk of carotid plaque in HIV-infected participants (risk ratio = 1.25 per standard deviation increment; 95% confidence interval, 1.05-1.50; P = .01). TMAO was positively correlated with biomarkers of monocyte activation and inflammation (sCD14, sCD163). Further adjustment for these biomarkers attenuated the association between TMAO and carotid plaque (P = .08). Among HIV-infected individuals, plasma TMAO was associated with carotid atherosclerosis progression, partially through immune activation and inflammation.
我们在 7 年内研究了 520 名 HIV 感染者和 217 名 HIV 未感染者（112 名新发病例）中 5 种血浆胆碱代谢物与颈动脉斑块之间的关联。经过多变量调整后，与肠道微生物群相关的代谢物三甲胺 N-氧化物（TMAO）较高与 HIV 感染者颈动脉斑块风险增加相关（风险比=每标准偏差增加 1.25；95%置信区间，1.05-1.50；P =.01）。TMAO 与单核细胞活化和炎症的生物标志物（sCD14、sCD163）呈正相关。进一步调整这些生物标志物减弱了 TMAO 与颈动脉斑块之间的关联（P =.08）。在 HIV 感染者中，血浆 TMAO 与颈动脉粥样硬化进展有关，部分通过免疫激活和炎症。
