Interdisciplinary Center for Aquaculture Research (INCAR), Department of Oceanography, Biotechnology Center, University of Concepción, Concepción, Chile.
Grupo de Marcadores Inmunológicos, Facultad de Ciencias, Instituto de Biología, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
Front Immunol. 2018 Jun 4;9:1241. doi: 10.3389/fimmu.2018.01241. eCollection 2018.
Ectotherms choose the best thermal conditions to mount a successful immune response, a phenomenon known as behavioral fever. The cumulative evidence suggests that behavioral fever impacts positively upon lymphocyte proliferation, inflammatory cytokine expression, and other immune functions. In this study, we have explored how thermal choice during infection impacts upon underpinning molecular processes and how temperature increase is coupled to the immune response. Our results show that behavioral fever results in a widespread, plastic imprint on gene regulation, and lymphocyte proliferation. We further explored the possible contribution of histone modification and identified global associations between temperature and histone changes that suggest epigenetic remodeling as a result of behavioral fever. Together, these results highlight the critical importance of thermal choice in mobile ectotherms, particularly in response to an infection, and demonstrate the key role of epigenetic modification to orchestrate the thermocoupling of the immune response during behavioral fever.
变温动物会选择最佳的热环境来成功地进行免疫反应，这种现象被称为行为性发热。累积的证据表明，行为性发热对淋巴细胞增殖、炎症细胞因子表达和其他免疫功能有积极影响。在这项研究中，我们探讨了感染期间的热选择如何影响潜在的分子过程，以及温度升高如何与免疫反应相关联。我们的结果表明，行为性发热导致基因调控和淋巴细胞增殖的广泛、可塑的印记。我们进一步探讨了组蛋白修饰的可能贡献，并确定了温度与组蛋白变化之间的全局关联，这表明行为性发热导致了表观遗传重塑。总之，这些结果强调了热选择在移动变温动物中的重要性，特别是在应对感染时，并且表明表观遗传修饰在行为性发热期间协调免疫反应的热偶联中起着关键作用。
