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Disorders of Taste and Smell.味觉和嗅觉障碍。
Continuum (Minneap Minn). 2017 Apr;23(2, Selected Topics in Outpatient Neurology):421-446. doi: 10.1212/CON.0000000000000463.
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Nutritional status and body composition by bioelectrical impedance vector analysis: A cross sectional study in mild cognitive impairment and Alzheimer's disease.通过生物电阻抗矢量分析评估营养状况和身体成分：一项针对轻度认知障碍和阿尔茨海默病的横断面研究。
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Taste detection and recognition thresholds in Japanese patients with Alzheimer-type dementia.日本阿尔茨海默病型痴呆患者的味觉检测和识别阈值
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Sleep Apnea, Sleep Duration and Brain MRI Markers of Cerebral Vascular Disease and Alzheimer's Disease: The Atherosclerosis Risk in Communities Study (ARIC).睡眠呼吸暂停、睡眠时间与脑血管疾病及阿尔茨海默病的脑磁共振成像标志物：社区动脉粥样硬化风险研究（ARIC）
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阿尔茨海默病患者的身体成分、饮食和味觉功能评估。

Body Composition, Dietary, and Gustatory Function Assessment in People With Alzheimer's Disease.

机构信息

1 Research Centers in Nutrition and Health (CINUSA group), Paseo de la Habana, Madrid, Spain.

2 Medicine Department, Universidad Complutense de Madrid, Plaza de Ramón y Cajal, Ciudad Universitaria, Madrid, Spain.

出版信息

Am J Alzheimers Dis Other Demen. 2018 Dec;33(8):508-515. doi: 10.1177/1533317518782173. Epub 2018 Jun 19.

DOI:10.1177/1533317518782173
PMID:29916258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10852479/
Abstract

OBJECTIVES

Observe the association of foods habits, body composition, lifestyle habits, and loss of gustatory function with Alzheimer's disease (AD).

METHODS

This comparative study enrolled 75 patients with AD (mean age 77.5 years) and 267 healthy volunteers (mean age 73 years). Weight, height, body mass index (BMI), body fat, visceral fat, muscle mass, and waist circumference were measured. Adherence to the Mediterranean diet was measured by the Mediterranean-Diet-Adherence Screener. Gustatory function was investigated using a threshold and triangle test.

RESULTS

Cases with AD presented lower BMI and weight and higher sleep hours, being statistically significant the difference between cases and controls ( P = .02; P = .001; P = .001, respectively). Patients with AD showed lower adherence to exercise and Mediterranean diet as shown by the Mediterranean Diet Adherence Screener-score (8.12 ± 2.5 vs 8.65 ± 2.4). The gustatory function was impaired in patients with AD when compared to controls.

CONCLUSION

Patients with AD show worst outcomes in terms of anthropometric measurements, lifestyle habits (diet, exercise), and gustatory function than controls.

摘要

目的

观察饮食习惯、身体成分、生活习惯以及味觉功能丧失与阿尔茨海默病（AD）的相关性。

方法

本项对比研究纳入了 75 名 AD 患者（平均年龄 77.5 岁）和 267 名健康志愿者（平均年龄 73 岁）。测量体重、身高、体重指数（BMI）、体脂肪、内脏脂肪、肌肉量和腰围。采用地中海饮食依从性筛查器来评估地中海饮食的依从性。使用阈值和三角测试来检测味觉功能。

结果

AD 患者的 BMI 和体重较低，睡眠时间较长，与对照组相比差异具有统计学意义（P =.02；P =.001；P =.001）。地中海饮食依从性筛查器评分显示，AD 患者的运动和地中海饮食依从性较低（8.12 ± 2.5 比 8.65 ± 2.4）。与对照组相比，AD 患者的味觉功能受损。

结论

与对照组相比，AD 患者在人体测量、生活习惯（饮食、运动）和味觉功能方面的结果更差。