Department of Chemistry and Pharmacy, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.
Nanoscale. 2018 Jul 5;10(25):11719-11731. doi: 10.1039/c8nr02796j.
In this review we provide a broad overview on the use of nanotechnology for the fight against breast cancer (BC). Nowadays, detection, diagnosis, treatment, and prevention may be possible thanks to the application of nanotechnology to clinical practice. Taking into consideration the different forms of BC and the disease status, nanomaterials can be designed to meet the most forefront objectives of modern therapy and diagnosis. We have analyzed in detail three main groups of nanomaterial applications for BC treatment and diagnosis. We have identified several types of drugs successfully conjugated with nanomaterials. We have analyzed the main important imaging techniques and all nanomaterials used to help the non-invasive, early detection of the lesions. Moreover, we have examined theranostic nanomaterials as unique tools, combining imaging, detection, and therapy for BC. This state of the art review provides a useful guide depicting how nanotechnology can be used to overcome the current barriers in BC clinical practice, and how it will shape the future scenario of treatments, prevention, and diagnosis, revolutionizing the current approaches, e.g., reducing the suffering related to chemotherapy.
在这篇综述中，我们提供了纳米技术在对抗乳腺癌 (BC) 中的应用的广泛概述。如今，由于将纳米技术应用于临床实践，检测、诊断、治疗和预防可能成为可能。考虑到 BC 的不同形式和疾病状况，可以设计纳米材料以满足现代治疗和诊断的最前沿目标。我们详细分析了用于 BC 治疗和诊断的三类主要纳米材料应用。我们已经确定了几种成功与纳米材料结合的药物类型。我们分析了主要的重要成像技术以及用于帮助非侵入性、早期检测病变的所有纳米材料。此外，我们研究了治疗诊断纳米材料作为独特的工具，将成像、检测和治疗结合起来用于 BC。这篇最新综述提供了一个有用的指南，描述了纳米技术如何用于克服 BC 临床实践中的当前障碍，以及它将如何塑造治疗、预防和诊断的未来前景，从而彻底改变当前的方法，例如，减少与化疗相关的痛苦。
