Department of Cardiovascular Medicine Ward I, The Second People's Hospital of Jiaozuo, The First Affiliated Hospital of Henan Polytechnic University, Jiaozuo, 454000, Henan Province, China.
Department of Cardiovascular Medicine Ward I, The Second People's Hospital of Jiaozuo, The First Affiliated Hospital of Henan Polytechnic University, Jiaozuo, 454000, Henan Province, China.
J Pharmacol Sci. 2018 Jun;137(2):110-115. doi: 10.1016/j.jphs.2018.05.006. Epub 2018 Jun 2.
Scoparone is a biologically active constituent isolated from Artemisia capillaris and possesses a variety of pharmacological activities, such as anti-inflammatory, anti-tumor, anti-allergic and anti-cardiovascular activities. However, there are no studies focusing on the effects of scoparone against cardiac fibrosis. Therefore, the aim of this study was to investigate the effects of scoparone on Angiotensin II (Ang II)-induced extracellular matrix (ECM) remodeling and its possible mechanism in cardiac fibroblasts (CFs). Our results demonstrated that scoparone effectively attenuated CFs proliferation in Ang II-stimulated CFs. Scoparone also prevented the differentiation of CFs to myofibroblasts and ECM proteins (type I collagen and fibronectin) expression in Ang II-stimulated CFs. Furthermore, scoparone prevented Ang II-induced the activation of TGF-β1/Smad signalling in CFs. Taken together, these studies indicated that scoparone attenuated Ang II-induced ECM remodeling in CFs, at least in part, by inhibiting TGF-β1/Smad signalling. These findings suggest that scoparone may be used a novel therapeutic agent against cardiac fibrosis.
贯叶金丝桃素是从青蒿中分离得到的一种具有生物活性的成分，具有多种药理活性，如抗炎、抗肿瘤、抗过敏和抗心血管活性。然而，目前还没有研究关注贯叶金丝桃素对心肌纤维化的作用。因此，本研究旨在探讨贯叶金丝桃素对血管紧张素 II（Ang II）诱导的心肌成纤维细胞（CFs）细胞外基质（ECM）重塑的影响及其可能的机制。研究结果表明，贯叶金丝桃素能有效抑制 Ang II 刺激的 CFs 增殖。贯叶金丝桃素还能阻止 CFs 向肌成纤维细胞分化以及 Ang II 刺激的 CFs 中 ECM 蛋白（I 型胶原和纤维连接蛋白）的表达。此外，贯叶金丝桃素能防止 Ang II 诱导的 CFs 中 TGF-β1/Smad 信号通路的激活。综上所述，这些研究表明，贯叶金丝桃素通过抑制 TGF-β1/Smad 信号通路，减轻 Ang II 诱导的 CFs 细胞外基质重塑，至少部分是通过抑制 TGF-β1/Smad 信号通路。这些发现提示贯叶金丝桃素可能成为一种新型的抗心肌纤维化治疗药物。
