Song Yinping, Jia Hao, Hua Yijie, Wu Chen, Li Sujuan, Li Kunzhe, Liang Zhicheng, Wang Youhua
Institute of Sports and Exercise Biology, School of Physical Education, Shaanxi Normal University, Xi'an, China.
School of Health and Sports, Xi'an Fanyi University, Xi'an, China.
Front Physiol. 2022 Feb 28;13:792292. doi: 10.3389/fphys.2022.792292. eCollection 2022.
The treatment and prevention of hypertension has been a worldwide medical challenge. The key pathological hallmark of hypertension is altered arterial vascular structure and function, i.e., increased peripheral vascular resistance due to vascular remodeling. The aim of this review is to elucidate the molecular mechanisms of vascular remodeling in hypertension and the protective mechanisms of aerobic exercise against vascular remodeling during the pathological process of hypertension. The main focus is on the mechanisms of oxidative stress and inflammation in the pathological condition of hypertension and vascular phenotypic transformation induced by the trilaminar structure of vascular endothelial cells, smooth muscle cells and extracellular matrix, and the peripheral adipose layer of the vasculature. To further explore the possible mechanisms by which aerobic exercise ameliorates vascular remodeling in the pathological process of hypertension through anti-proliferative, anti-inflammatory, antioxidant and thus inhibiting vascular phenotypic transformation. It provides a new perspective to reveal the intervention targets of vascular remodeling for the prevention and treatment of hypertension and its complications.
高血压的治疗与预防一直是一项全球性的医学挑战。高血压的关键病理特征是动脉血管结构和功能改变，即由于血管重塑导致外周血管阻力增加。本综述的目的是阐明高血压中血管重塑的分子机制以及有氧运动在高血压病理过程中对抗血管重塑的保护机制。主要关注高血压病理状态下氧化应激和炎症的机制，以及由血管内皮细胞、平滑肌细胞、细胞外基质的三层结构和血管外周脂肪层诱导的血管表型转化。进一步探讨有氧运动通过抗增殖、抗炎、抗氧化从而抑制血管表型转化来改善高血压病理过程中血管重塑的可能机制。它为揭示血管重塑的干预靶点以预防和治疗高血压及其并发症提供了新的视角。
