二氢槲皮素及其配合物的特性、抗氧化和抗肿瘤活性研究。

Research on Characteristics, Antioxidant and Antitumor Activities of Dihydroquercetin and Its Complexes.

机构信息

Key Laboratory of Food Nutrition and Safety, Ministry of Education, School of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.

出版信息

Molecules. 2017 Dec 22;23(1):20. doi: 10.3390/molecules23010020.

Dihydroquercetin is a kind of dihydroflavonol compounds with antioxidant, antitumor, antivirus and radioresistance activities. This study attempted to produce the dihydroquercetin complexes with lecithin and β-cyclodextrin, and research their characteristics and bioactivities via ultraviolet spectrum (UV), infrared spectroscopy (IR), scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray diffraction spectrum (XRD), and MTT assay. Results showed that the complexes with lecithin and β-cyclodextrin could improve the solubility and dissolution rate, and remove the characteristic endothermic peak of dihydroquercetin. IR spectra proved their interaction, and results of SEM and XRD showed the amorphous characteristics of the dihydroquercetin compounds. These results indicated that dihydroquercetin was combined by lecithin or β-cyclodextrin with better physical and chemical properties, which would effectively improve the application value in the food and drug industries.

二氢槲皮素是一种二氢黄酮醇类化合物，具有抗氧化、抗肿瘤、抗病毒和抗辐射等活性。本研究试图制备二氢槲皮素与卵磷脂和β-环糊精的复合物，并通过紫外光谱（UV）、红外光谱（IR）、扫描电子显微镜（SEM）、差示扫描量热法（DSC）、X 射线衍射谱（XRD）和 MTT 测定法研究其特性和生物活性。结果表明，与卵磷脂和β-环糊精形成的复合物可以提高二氢槲皮素的溶解度和溶解速率，并消除其特征吸热峰。IR 光谱证明了它们的相互作用，SEM 和 XRD 的结果表明二氢槲皮素化合物具有无定形特征。这些结果表明，二氢槲皮素与卵磷脂或β-环糊精结合后具有更好的物理化学性质，这将有效提高其在食品和医药工业中的应用价值。