神经毒理学遗传学中的性别差异
Sex Differences in Neurotoxicogenetics.
作者信息
Torres-Rojas Carolina, Jones Byron C
机构信息
Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN, United States.
Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.
出版信息
Front Genet. 2018 Jun 5;9:196. doi: 10.3389/fgene.2018.00196. eCollection 2018.
Abstract
A major development in biomedical research is the recognition that the sex of an individual plays a key role in susceptibility, treatment, and outcomes of most diseases. In this contribution, we present evidence that sex is also important in the toxicity of many environmental toxicants and contributes to the effect of genetics. Thus, individual differences in response to toxicants includes genetic makeup, the environment and sex; in fact, sex differences may be considered a part of genetic constitution. In this review, we present evidence for sex contribution to susceptibility for a number of toxicants.
摘要
生物医学研究的一项重大进展是认识到个体的性别在大多数疾病的易感性、治疗和结果中起着关键作用。在本论文中，我们提供证据表明性别在许多环境毒物的毒性中也很重要，并对遗传学效应有影响。因此，个体对毒物反应的差异包括基因组成、环境和性别；事实上，性别差异可被视为基因构成的一部分。在这篇综述中，我们提供了性别对多种毒物易感性有影响的证据。
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