MOE Key Laboratory of Contemporary Anthropology, Fudan University, Shanghai, 20043, China.
Collaborative Innovation Center of Genetics and Development, Shanghai, 200438, China.
Mol Genet Genomics. 2018 Oct;293(5):1293-1300. doi: 10.1007/s00438-018-1461-2. Epub 2018 Jun 19.
Diffusion of Tibeto-Burman populations across the Tibetan Plateau led to the largest human community in a high-altitude environment and has long been a focus of research on high-altitude adaptation, archeology, genetics, and linguistics. However, much uncertainty remains regarding the origin, diversification, and expansion of Tibeto-Burman populations. In this study, we analyzed a 7.0M bp region of 285 Y-chromosome sequences, including 81 newly reported ones, from male samples from Tibeto-Burman populations and other related Eastern Asian populations. We identified several paternal lineages specific to Tibeto-Burman populations, and most of these lineages emerged between 6000 and 2500 years ago. A phylogenetic tree and lineage dating both support the hypothesis that the establishment of Tibeto-Burman ancestral groups was triggered by Neolithic expansions from the middle Yellow River Basin and admixtures with local populations on the Tibetan Plateau who survived the Paleolithic Age. Furthermore, according to the geographical distributions of the haplogroups, we propose that there are two Neolithic expansion origins for all modern Tibeto-Burman populations. Our research provides a clear scenario about the sources, admixture process and later diffusion process of the ancestor population of all Tibeto-Burman populations.
藏缅族群在青藏高原上的扩散导致了高海拔环境中最大的人类群体，长期以来一直是高海拔适应、考古学、遗传学和语言学研究的焦点。然而，关于藏缅族群的起源、多样化和扩张仍然存在很多不确定性。在这项研究中，我们分析了来自藏缅族群和其他相关东亚族群的 285 个 Y 染色体序列的 7.0Mbp 区域，其中包括 81 个新报告的序列。我们鉴定了几个特定于藏缅族群的父系谱系，这些谱系大多在 6000 到 2500 年前出现。系统发育树和谱系年代分析都支持这样的假设，即藏缅族群祖先群体的建立是由新石器时代从中黄河流域的扩张以及与在旧石器时代幸存下来的高原当地人群的混合所引发的。此外，根据单倍群的地理分布，我们提出所有现代藏缅族群都有两个新石器时代的扩张起源。我们的研究提供了一个关于所有藏缅族群祖先群体的来源、混合过程和后来扩散过程的清晰情景。
