Department of Chemistry and Biochemistry, University of California at Los Angeles, 607 Charles E Young Drive East, Los Angeles, CA, 90095-1569, USA.
Research Group for NMR Signal Enhancement, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Göttingen, Germany.
Angew Chem Int Ed Engl. 2018 Aug 13;57(33):10692-10696. doi: 10.1002/anie.201804185. Epub 2018 Jul 9.
Hyperpolarization techniques are key to extending the capabilities of MRI for the investigation of structural, functional and metabolic processes in vivo. Recent heterogeneous catalyst development has produced high polarization in water using parahydrogen with biologically relevant contrast agents. A heterogeneous ligand-stabilized Rh catalyst is introduced that is capable of achieving N polarization of 12.2±2.7 % by hydrogenation of neurine into a choline derivative. This is the highest N polarization of any parahydrogen method in water to date. Notably, this was performed using a deuterated quaternary amine with an exceptionally long spin-lattice relaxation time (T ) of 21.0±0.4 min. These results open the door to the possibility of N in vivo imaging using nontoxic similar model systems because of the biocompatibility of the production media and the stability of the heterogeneous catalyst using parahydrogen-induced polarization (PHIP) as the hyperpolarization method.
极化技术是扩展 MRI 在体内研究结构、功能和代谢过程能力的关键。最近的多相催化剂的发展使用仲氢产生了具有生物学相关对比剂的高极化。本文介绍了一种多相配体稳定的 Rh 催化剂，它能够通过将神经氨酸氢化生成胆碱衍生物，实现 12.2±2.7%的 N 极化。这是迄今为止水中使用仲氢方法获得的最高 N 极化。值得注意的是，这是使用具有异常长自旋晶格弛豫时间（T）的氘化季铵盐，在 21.0±0.4 分钟内完成的。由于产生介质的生物相容性和使用仲氢诱导极化（PHIP）作为极化方法的多相催化剂的稳定性，这些结果为使用类似的无毒模型系统进行体内 N 成像开辟了可能性。
