Moore G J, Matsoukas J M
Biosci Rep. 1985 May;5(5):407-16. doi: 10.1007/BF01116558.
Proton magnetic resonance and chemical reactivity studies have demonstrated the presence of a tyrosine charge relay system in angiotensin which is analogous to the serine charge relay system present at the active site of serine proteases. Receptor activation by angiotensin can be explained by electronic effects deriving from an interaction of the charge relay system with stacking of the histidine and phenylalanine rings. Experiments with serine protease inhibitors suggest the possibility that mechanistic features of the interaction of angiotensin with its receptors may apply to other 'phenoxyl' hormones including certain peptides, steroids and catecholamines.
质子磁共振和化学反应性研究表明，血管紧张素中存在酪氨酸电荷中继系统，这类似于丝氨酸蛋白酶活性位点处存在的丝氨酸电荷中继系统。血管紧张素对受体的激活可以通过电荷中继系统与组氨酸和苯丙氨酸环堆积相互作用产生的电子效应来解释。使用丝氨酸蛋白酶抑制剂的实验表明，血管紧张素与其受体相互作用的机制特征可能适用于其他“苯氧基”激素，包括某些肽、类固醇和儿茶酚胺。
