Shanghai Key Laboratory of Functional Materials Chemistry, Key Laboratory for Specially Functional Polymeric Materials and Related Technology of the Ministry of Education, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Chem Commun (Camb). 2018 Jul 14;54(55):7629-7632. doi: 10.1039/c8cc04275f. Epub 2018 Jun 21.
A supramolecular nanovesicle was constructed by complexation between pyrophaeophorbide A (PPhA) and water-soluble pillar[5]arene, and then a biotin-pyridinium targeting agent was introduced to its surface. This nanovesicle exhibited reduced aggregation of PPhA photosensitizers and high targeting ability towards cancer cells, thereby leading to excellent therapeutic efficacy under red light.
超分子纳米囊泡通过焦脱镁叶绿酸 A（PPhA）与水溶性杯[5]芳烃的络合作用构建而成，然后在其表面引入生物素-吡啶鎓靶向剂。这种纳米囊泡表现出 PPhA 光敏剂聚集减少和对癌细胞的高靶向能力，从而在红光下表现出优异的治疗效果。
