McKinney J D, Chae K, McConnell E E, Birnbaum L S
Environ Health Perspect. 1985 May;60:57-68. doi: 10.1289/ehp.856057.
A comparison of the structure-induction (involving rat and mouse Ah receptor binding) and structure-toxicity (in vivo guinea pig toxicity) relationships suggests that two receptors with structurally distinct binding properties may be involved. This is supported by demonstration of potentiated toxicity through a mechanism believed to involve the Ah receptor as a site of loss with respect to toxicity. Theoretical and working models are proposed for these separate receptors to aid in the search for other relevant binding proteins. The findings suggest that polychlorinated biphenyls that are relatively low in toxicity may have modulating properties on the action of highly toxic compounds with which they are normally found in the environment.
对结构诱导（涉及大鼠和小鼠芳烃受体结合）与结构-毒性（体内豚鼠毒性）关系的比较表明，可能涉及两种具有结构不同结合特性的受体。通过一种据信涉及芳烃受体作为毒性损失位点的机制所证明的增强毒性，支持了这一观点。针对这些不同的受体提出了理论模型和工作模型，以帮助寻找其他相关的结合蛋白。研究结果表明，毒性相对较低的多氯联苯可能对环境中通常与之共存的高毒性化合物的作用具有调节特性。
