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克隆工作犬的健康与性情

Health and temperaments of cloned working dogs.

作者信息

Kim Min Jung, Oh Hyun Ju, Hwang Sun Young, Hur Tai Young, Lee Byeong Chun

机构信息

Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.

Haemaru Referral Animal Hospital and Small Animal Clinical Research Institute, Seongnam 13590, Korea.

出版信息

J Vet Sci. 2018 Sep 30;19(5):585-591. doi: 10.4142/jvs.2018.19.5.585.

DOI:10.4142/jvs.2018.19.5.585
PMID:29929355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6167335/
Abstract

Dogs serve human society in various ways by working at tasks that are based on their superior olfactory sensitivity. However, it has been reported that only about half of all trained dogs may qualify as working dogs through conventional breeding management because proper temperament and health are needed in addition to their innate scent detection ability. To overcome this low efficiency of breeding qualified working dogs, and to reduce the enormous costs of maintaining unqualified dogs, somatic cell nuclear transfer has been applied in the propagation of working dogs. Herein, we review the history of cloning working dogs and evaluate the health development, temperaments, and behavioral similarities among the cloned dogs. We also discuss concerns about dog cloning including those related to birth defects, lifespan, and cloning efficiency.

摘要

狗通过执行基于其卓越嗅觉灵敏度的任务,以各种方式服务于人类社会。然而,据报道,在所有经过训练的狗中,只有大约一半能够通过传统的繁殖管理成为工作犬,因为除了天生的气味检测能力外,还需要具备适当的性情和健康状况。为了克服培育合格工作犬效率低下的问题,并降低饲养不合格犬只的巨大成本,体细胞核移植已被应用于工作犬的繁殖。在此,我们回顾了克隆工作犬的历史,并评估了克隆犬的健康发育、性情以及行为相似性。我们还讨论了有关狗克隆的问题,包括与出生缺陷、寿命和克隆效率相关的问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/909f/6167335/9c0c6b12f331/jvs-19-585-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/909f/6167335/9c0c6b12f331/jvs-19-585-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/909f/6167335/9c0c6b12f331/jvs-19-585-g001.jpg

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本文引用的文献

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Birth of clones of the world's first cloned dog.世界首例克隆犬的克隆体诞生。
Sci Rep. 2017 Nov 10;7(1):15235. doi: 10.1038/s41598-017-15328-2.
2
Environmental and Physiological Factors Associated With Stamina in Dogs Exercising in High Ambient Temperatures.与在高环境温度下运动的犬类耐力相关的环境和生理因素。
Front Vet Sci. 2017 Sep 11;4:144. doi: 10.3389/fvets.2017.00144. eCollection 2017.
3
A National Census of Birth Weight in Purebred Dogs in Italy.意大利纯种犬出生体重全国普查。
酶联荧光分析法(ELFA)在通过评估孕酮水平获取体内成熟犬卵母细胞中的应用。
Animals (Basel). 2023 Jun 5;13(11):1885. doi: 10.3390/ani13111885.
4
Detour test performance of cloned minipigs from three different clone populations.绕道测试来自三个不同克隆群体的克隆小型猪的性能。
Vet Res Commun. 2023 Dec;47(4):2137-2144. doi: 10.1007/s11259-023-10168-0. Epub 2023 Jul 15.
5
Live births from urine derived cells.尿源细胞孕育的活体。
PLoS One. 2023 Jan 25;18(1):e0278607. doi: 10.1371/journal.pone.0278607. eCollection 2023.
6
Brachygnathia Inferior in Cloned Dogs Is Possibly Correlated with Variants of Wnt Signaling Pathway Initiators.克隆犬下颌骨发育不全可能与 Wnt 信号通路起始因子的变异有关。
Int J Mol Sci. 2022 Jan 1;23(1):475. doi: 10.3390/ijms23010475.
Animals (Basel). 2017 May 30;7(6):43. doi: 10.3390/ani7060043.
4
Learning, memory and exploratory similarities in genetically identical cloned dogs.基因相同的克隆犬在学习、记忆和探索方面的相似性。
J Vet Sci. 2016 Dec 30;17(4):563-567. doi: 10.4142/jvs.2016.17.4.563.
5
Cloning of the short-tailed Gyeongju Donggyeong dog via SCNT: conserving phenotypic inheritance.通过体细胞核移植克隆短尾庆州东基犬:保存表型遗传
J Vet Med Sci. 2016 Feb;78(2):329-31. doi: 10.1292/jvms.15-0107. Epub 2015 Oct 19.
6
Propagation of elite rescue dogs by somatic cell nuclear transfer.通过体细胞核移植繁殖精英搜救犬。
Anim Sci J. 2016 Jan;87(1):21-6. doi: 10.1111/asj.12402. Epub 2015 Aug 7.
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Altering histone acetylation status in donor cells with suberoylanilide hydroxamic acid does not affect dog cloning efficiency.用辛二酰苯胺异羟肟酸改变供体细胞中的组蛋白乙酰化状态不会影响犬类克隆效率。
Theriogenology. 2015 Oct 15;84(7):1256-61. doi: 10.1016/j.theriogenology.2015.07.006. Epub 2015 Jul 13.
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Ectopic liver and gallbladder in a cloned dog: Possible nonheritable anomaly.克隆犬中的异位肝脏和胆囊:可能的非遗传性异常。
Theriogenology. 2015 Oct 1;84(6):995-1002. doi: 10.1016/j.theriogenology.2015.05.039. Epub 2015 Jun 11.
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Effect of primary culture medium type for culture of canine fibroblasts on production of cloned dogs.原代培养基类型对犬成纤维细胞培养及克隆犬生产的影响。
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Reduced birth weight, cleft palate and preputial abnormalities in a cloned dog.克隆犬出现出生体重降低、腭裂和包皮异常。
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