• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Chromosomal Conformations and Epigenomic Regulation in Schizophrenia.精神分裂症中的染色体构象和表观基因组调控。
Prog Mol Biol Transl Sci. 2018;157:21-40. doi: 10.1016/bs.pmbts.2017.11.022. Epub 2018 Mar 30.
2
Epigenetic mechanisms in schizophrenia.精神分裂症中的表观遗传机制。
Dialogues Clin Neurosci. 2014 Sep;16(3):405-17. doi: 10.31887/DCNS.2014.16.3/sakbarian.
3
The epigenomics of schizophrenia, in the mouse.小鼠精神分裂症的表观基因组学
Am J Med Genet B Neuropsychiatr Genet. 2017 Sep;174(6):631-640. doi: 10.1002/ajmg.b.32566. Epub 2017 Jul 12.
4
The genome in three dimensions: a new frontier in human brain research.三维基因组：人类大脑研究的新前沿。
Biol Psychiatry. 2014 Jun 15;75(12):961-9. doi: 10.1016/j.biopsych.2013.07.015. Epub 2013 Aug 16.
5
3D Genome Plasticity in Normal and Diseased Neurodevelopment.三维基因组在正常和病变神经发育中的可塑作用。
Genes (Basel). 2022 Nov 1;13(11):1999. doi: 10.3390/genes13111999.
6
Interneuron epigenomes during the critical period of cortical plasticity: Implications for schizophrenia.皮质可塑性关键期的中间神经元表观基因组：对精神分裂症的启示
Neurobiol Learn Mem. 2015 Oct;124:104-10. doi: 10.1016/j.nlm.2015.03.005. Epub 2015 Apr 4.
7
Connecting high-resolution 3D chromatin organization with epigenomics.连接高分辨率 3D 染色质构象与表观基因组学。
Nat Commun. 2022 Apr 19;13(1):2054. doi: 10.1038/s41467-022-29695-6.
8
Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk.与精神分裂症风险相关的染色体连接组中的神经元特异性特征。
Science. 2018 Dec 14;362(6420). doi: 10.1126/science.aat4311.
9
Chromosome conformation elucidates regulatory relationships in developing human brain.染色体构象揭示了发育中的人类大脑中的调控关系。
Nature. 2016 Oct 27;538(7626):523-527. doi: 10.1038/nature19847. Epub 2016 Oct 19.
10
Transcriptional regulation of GAD1 GABA synthesis gene in the prefrontal cortex of subjects with schizophrenia.精神分裂症患者前额叶皮质中GAD1 GABA合成基因的转录调控
Schizophr Res. 2015 Sep;167(1-3):28-34. doi: 10.1016/j.schres.2014.10.020. Epub 2014 Oct 31.

引用本文的文献

1
The Correlation Between Peripheral Blood Micro-Ribonucleic Acid Expression Level and Personality Disorder in Patients with Schizophrenia.精神分裂症患者外周血微小核糖核酸表达水平与人格障碍的相关性
Alpha Psychiatry. 2024 Jan 1;25(1):23-29. doi: 10.5152/alphapsychiatry.2024.231216. eCollection 2024 Jan.
2
Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles.内侧神经节隆起中Ezh2的缺失会改变中间神经元的命运、细胞形态和基因表达谱。
Front Cell Neurosci. 2024 Feb 14;18:1334244. doi: 10.3389/fncel.2024.1334244. eCollection 2024.
3
DNA methylation and the opposing NMDAR dysfunction in schizophrenia and major depression disorders: a converging model for the therapeutic effects of psychedelic compounds in the treatment of psychiatric illness.精神分裂症和重度抑郁症中的 DNA 甲基化和相反的 NMDA 功能障碍：致幻化合物治疗精神疾病的疗效的汇聚模型。
Mol Psychiatry. 2023 Nov;28(11):4553-4567. doi: 10.1038/s41380-023-02235-4. Epub 2023 Sep 7.
4
Epigenetics of cognition and behavior: insights from Mendelian disorders of epigenetic machinery.认知和行为的表观遗传学：来自表观遗传机制 Mendelian 疾病的见解。
J Neurodev Disord. 2023 May 27;15(1):16. doi: 10.1186/s11689-023-09482-0.
5
Gene Expression and Epigenetic Regulation in the Prefrontal Cortex of Schizophrenia.精神分裂症前额叶皮层中的基因表达和表观遗传调控。
Genes (Basel). 2023 Jan 18;14(2):243. doi: 10.3390/genes14020243.
6
L-type calcium channels and neuropsychiatric diseases: Insights into genetic risk variant-associated genomic regulation and impact on brain development.L 型钙通道与神经精神疾病：遗传风险变异相关的基因组调控及对大脑发育影响的研究进展。
Channels (Austin). 2023 Dec;17(1):2176984. doi: 10.1080/19336950.2023.2176984.
7
Editorial: Neuroepigenetics of Neuropsychiatric Disease-Hope, Success and Obstacles for Translational Findings and Applications.社论：神经精神疾病的神经表观遗传学——转化研究成果与应用的希望、成功与障碍
Front Neurosci. 2022 Apr 1;16:886695. doi: 10.3389/fnins.2022.886695. eCollection 2022.
8
Loop Interrupted: Dysfunctional Chromatin Relations in Neurological Diseases.循环中断：神经疾病中的染色质功能失调关系
Front Genet. 2021 Aug 5;12:732033. doi: 10.3389/fgene.2021.732033. eCollection 2021.
9
Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications.前额叶皮层突触传递失调的机制：病理生理学意义。
Mol Psychiatry. 2022 Jan;27(1):445-465. doi: 10.1038/s41380-021-01092-3. Epub 2021 Apr 19.
10
Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells.利用人类诱导多能干细胞对精神分裂症的研究。
Adv Neurobiol. 2020;25:155-206. doi: 10.1007/978-3-030-45493-7_6.

本文引用的文献

1
The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.甲基转移酶SETDB1调控一个大的神经元特异性拓扑染色质结构域。
Nat Genet. 2017 Aug;49(8):1239-1250. doi: 10.1038/ng.3906. Epub 2017 Jul 3.
2
DNA methylation as a putative mechanism for reduced dendritic spine density in the superior temporal gyrus of subjects with schizophrenia.DNA甲基化作为精神分裂症患者颞上回树突棘密度降低的一种潜在机制。
Transl Psychiatry. 2017 Feb 14;7(2):e1032. doi: 10.1038/tp.2016.297.
3
Multiplex gene editing by CRISPR-Cpf1 using a single crRNA array.使用单个crRNA阵列通过CRISPR-Cpf1进行多重基因编辑。
Nat Biotechnol. 2017 Jan;35(1):31-34. doi: 10.1038/nbt.3737. Epub 2016 Dec 5.
4
From profiles to function in epigenomics.从表观基因组学到功能。
Nat Rev Genet. 2017 Jan;18(1):51-66. doi: 10.1038/nrg.2016.138. Epub 2016 Nov 21.
5
Human GRIN2B variants in neurodevelopmental disorders.神经发育障碍中的人类GRIN2B基因变异体。
J Pharmacol Sci. 2016 Oct;132(2):115-121. doi: 10.1016/j.jphs.2016.10.002. Epub 2016 Oct 19.
6
Translating genome-wide association findings into new therapeutics for psychiatry.将全基因组关联研究结果转化为精神科的新疗法。
Nat Neurosci. 2016 Oct 26;19(11):1392-1396. doi: 10.1038/nn.4411.
7
Chromosome conformation elucidates regulatory relationships in developing human brain.染色体构象揭示了发育中的人类大脑中的调控关系。
Nature. 2016 Oct 27;538(7626):523-527. doi: 10.1038/nature19847. Epub 2016 Oct 19.
8
Spatial genome organization and cognition.空间基因组组织与认知。
Nat Rev Neurosci. 2016 Nov;17(11):681-691. doi: 10.1038/nrn.2016.124. Epub 2016 Oct 6.
9
Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia.4877名精神分裂症患者中极罕见的蛋白质改变变体负担增加。
Nat Neurosci. 2016 Nov;19(11):1433-1441. doi: 10.1038/nn.4402. Epub 2016 Oct 3.
10
Patterns of genic intolerance of rare copy number variation in 59,898 human exomes.59898份人类外显子组中罕见拷贝数变异的基因不耐受模式
Nat Genet. 2016 Oct;48(10):1107-11. doi: 10.1038/ng.3638. Epub 2016 Aug 17.

精神分裂症中的染色体构象和表观基因组调控。

Chromosomal Conformations and Epigenomic Regulation in Schizophrenia.

机构信息

Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Icahn School of Medicine at Mount Sinai, New York, NY, United States.

出版信息

Prog Mol Biol Transl Sci. 2018;157:21-40. doi: 10.1016/bs.pmbts.2017.11.022. Epub 2018 Mar 30.

DOI:10.1016/bs.pmbts.2017.11.022
PMID:29933951
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6318347/
Abstract

Chromosomal conformations, including promoter-enhancer loops, provide a critical regulatory layer for the transcriptional machinery. Therefore, schizophrenia, a common psychiatric disorder associated with broad changes in neuronal gene expression in prefrontal cortex and other brain regions implicated in psychosis, could be associated with alterations in higher-order chromatin. Here, we review early studies on spatial genome organization in the schizophrenia postmortem brain and discuss how integrative approaches using cell culture and animal model systems could gain deeper insight into the potential roles of higher-order chromatin for the neurobiology of and novel treatment avenues for common psychiatric disease.

摘要

染色体构象，包括启动子增强子环，为转录机制提供了一个关键的调控层。因此，精神分裂症是一种常见的精神疾病，与前额叶皮层和其他与精神病相关的脑区神经元基因表达的广泛变化有关，它可能与高级染色质的改变有关。在这里，我们回顾了精神分裂症尸检大脑中空间基因组组织的早期研究，并讨论了如何使用细胞培养和动物模型系统的综合方法，深入了解高级染色质对常见精神疾病的神经生物学和新的治疗途径的潜在作用。