精神分裂症中的染色体构象和表观基因组调控。
Chromosomal Conformations and Epigenomic Regulation in Schizophrenia.
机构信息
Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Icahn School of Medicine at Mount Sinai, New York, NY, United States.
出版信息
Prog Mol Biol Transl Sci. 2018;157:21-40. doi: 10.1016/bs.pmbts.2017.11.022. Epub 2018 Mar 30.
Abstract
Chromosomal conformations, including promoter-enhancer loops, provide a critical regulatory layer for the transcriptional machinery. Therefore, schizophrenia, a common psychiatric disorder associated with broad changes in neuronal gene expression in prefrontal cortex and other brain regions implicated in psychosis, could be associated with alterations in higher-order chromatin. Here, we review early studies on spatial genome organization in the schizophrenia postmortem brain and discuss how integrative approaches using cell culture and animal model systems could gain deeper insight into the potential roles of higher-order chromatin for the neurobiology of and novel treatment avenues for common psychiatric disease.
摘要
染色体构象，包括启动子增强子环，为转录机制提供了一个关键的调控层。因此，精神分裂症是一种常见的精神疾病，与前额叶皮层和其他与精神病相关的脑区神经元基因表达的广泛变化有关，它可能与高级染色质的改变有关。在这里，我们回顾了精神分裂症尸检大脑中空间基因组组织的早期研究，并讨论了如何使用细胞培养和动物模型系统的综合方法，深入了解高级染色质对常见精神疾病的神经生物学和新的治疗途径的潜在作用。
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