Dmitrichenko Olga, Mou Yuchan, Voortman Trudy, White Tonya, Jansen Pauline W
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.
The Generation R Study Group, Erasmus University Medical Center, Rotterdam, Netherlands.
Front Nutr. 2022 Apr 4;9:846148. doi: 10.3389/fnut.2022.846148. eCollection 2022.
Food-approach eating behaviors are associated with an increased risk of developing overweight/obesity and binge-eating disorder, while obesity and binge-eating disorder have also been linked with altered brain morphology in adults. To understand these associations, we examined the association of food-approach eating behaviors during childhood with adolescents' brain morphology. The sample included 1,781 adolescents with assessments of eating behaviors at ages 4 and 10 years and brain imaging data at 13 years from a large, population-based cohort. Food approach eating behaviors (enjoyment of food, emotional overeating, and food responsiveness) were assessed using the Child Eating Behavior Questionnaire. Additionally, we assessed binge eating symptoms using two items from the Development and Well-Being Assessment at 13 years of age. Adolescents participated in an MRI procedure and measures of brain morphology, including cerebral white, cerebral gray and subcortical gray matter volumes, were extracted from T1-weighted images processed using FreeSurfer. Enjoyment of food and food responsiveness at the age of 4 and 10 years were positively associated with cerebral white matter and subcortical gray matter volumes at age 13 years (e.g., enjoyment of food at 4 years and cerebral white matter: β = 2.73, 95% CI 0.51, 4.91). Enjoyment of food and food responsiveness at 4 years of age, but not at 10 years, were associated with a larger cerebral gray matter volume at 13 years of age (e.g., enjoyment of food at 4 years: β = 0.24, 95% CI 0.03, 0.45). No statistically significant associations were found for emotional overeating at both ages and brain measurements at 13 years of age. analyses showed no associations of food-approach eating behaviors with amygdala or hippocampus. Lastly, we did not observe significant associations of binge-eating symptoms with global brain measurements and a priori-defined regions of interest, including the right frontal operculum, insular and orbitofrontal cortex. Our findings support an association between food-approach eating behaviors, especially enjoyment of food and food responsiveness, and brain morphology in adolescence. Our findings add important knowledge to previous studies that were mostly conducted in adults, by suggesting that the eating behavior-brain link may be visible earlier in life. Further research is needed to determine causality.
趋近食物的进食行为与超重/肥胖及暴饮暴食症的发病风险增加有关，而肥胖和暴饮暴食症也与成年人脑形态改变有关。为了解这些关联，我们研究了儿童期趋近食物的进食行为与青少年脑形态之间的关联。样本包括1781名青少年，他们在4岁和10岁时接受了进食行为评估，并在13岁时从一个大型的基于人群的队列中获取了脑成像数据。使用儿童进食行为问卷评估趋近食物的进食行为（对食物的喜爱、情绪化暴饮暴食和食物反应性）。此外，我们在13岁时使用发育与幸福感评估中的两个项目评估暴饮暴食症状。青少年参与了MRI检查，并从使用FreeSurfer处理的T1加权图像中提取脑形态测量数据，包括脑白质、脑灰质和皮质下灰质体积。4岁和10岁时对食物的喜爱和食物反应性与13岁时的脑白质和皮质下灰质体积呈正相关（例如，4岁时对食物的喜爱与脑白质：β = 2.73，95%CI 0.51，4.91）。4岁时对食物的喜爱和食物反应性与13岁时更大的脑灰质体积有关，但10岁时无关（例如，4岁时对食物的喜爱：β = 0.24，95%CI 0.03，0.45）。在两个年龄阶段的情绪化暴饮暴食与13岁时的脑测量指标之间未发现统计学上的显著关联。分析显示，趋近食物的进食行为与杏仁核或海马体无关联。最后，我们未观察到暴饮暴食症状与全脑测量指标以及预先定义的感兴趣区域（包括右侧额下回、岛叶和眶额皮质）之间存在显著关联。我们的研究结果支持趋近食物的进食行为，尤其是对食物的喜爱和食物反应性，与青少年脑形态之间存在关联。我们的研究结果为之前大多在成年人中进行的研究增添了重要知识，表明进食行为与大脑的联系可能在生命早期就已显现。需要进一步研究来确定因果关系。
