Jang Dongsung, Yoon Joon, Taye Mengistie, Lee Wonseok, Kwon Taehyung, Shim Seunghyun, Kim Heebal
Interdisciplinary Program in Agricultural Genomics, Seoul National University, Seoul, Republic of Korea.
Department of Natural Science, Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea.
Genes Genomics. 2018 Jul;40(7):701-705. doi: 10.1007/s13258-018-0672-6. Epub 2018 Mar 26.
Genome-wide association studies (GWAS) have been steadily used for identification of genomic links to disease and various economical traits. Of those traits, a tenderness of pork is one of the most important factors in quality evaluation of consumers. In this study, we use two pig breed populations; Berkshire is known for its excellent meat quality and Duroc which is known for its high intramuscular fat content in meat. Multivariate genome-wide association studies (MV-GWAS) was executed to compare SNPs of two pigs to find out what genetic variants occur the tenderness of pork. Through MV-GWAS, we have identified candidate genes and the association of biological pathways involved in the tenderness of pork. From these direct and indirect associations, we displayed the usefulness of simple statistical models and their potential contribution to improving the meat quality of pork. We identified a candidate gene related to the tenderness in only Berkshire. Furthermore, several of the biological pathways involved in tenderness in both Berkshire and Duroc were found. The candidate genes identified in this study will be helpful to use them in breeding programs for improving pork quality.
全基因组关联研究（GWAS）已被持续用于识别与疾病及各种经济性状相关的基因组联系。在这些性状中，猪肉的嫩度是消费者质量评估的最重要因素之一。在本研究中，我们使用了两个猪品种群体；伯克夏猪以其优良的肉质而闻名，杜洛克猪则以其肉中高肌内脂肪含量而闻名。进行了多变量全基因组关联研究（MV-GWAS）以比较两种猪的单核苷酸多态性（SNP），以找出导致猪肉嫩度的基因变异。通过MV-GWAS，我们确定了候选基因以及与猪肉嫩度相关的生物途径的关联。从这些直接和间接关联中，我们展示了简单统计模型的实用性及其对改善猪肉肉质的潜在贡献。我们仅在伯克夏猪中鉴定出一个与嫩度相关的候选基因。此外，还发现了伯克夏猪和杜洛克猪中与嫩度相关的几种生物途径。本研究中鉴定出的候选基因将有助于在育种计划中利用它们来改善猪肉品质。
