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不常见的假阳性[F]flutemetamol PET 信号通过神经原纤维和弥漫性斑块的联合组织学评估得到解决。

Infrequent false positive [F]flutemetamol PET signal is resolved by combined histological assessment of neuritic and diffuse plaques.

机构信息

Departments of Neurology and Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.

出版信息

Alzheimers Res Ther. 2018 Jun 23;10(1):60. doi: 10.1186/s13195-018-0387-6.

DOI:10.1186/s13195-018-0387-6
PMID:29935545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6015459/
Abstract

BACKGROUND

The performance of [F]flutemetamol amyloid PET against histopathological standards of truth was the subject of our recent article in Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring (2017;9:25-34).

MAIN BODY

This viewpoint article addresses infrequently observed discordance between visual [F]flutemetamol PET image readings and histopathology based solely on neuritic plaque assessment by CERAD criteria, which is resolved by assessing both neuritic and diffuse plaques and/or brain atrophy.

CONCLUSION

[F]flutemetamol PET signal corresponds predominantly to neuritic plaque pathology but is also influenced by the presence of diffuse plaques. This could allow for detection of diffuse amyloid deposits in the early stages of AD dementia, particularly in the striatum where diffuse amyloid is most commonly observed.

摘要

背景

[F]flutemetamol 淀粉样蛋白 PET 对组织病理学标准的性能是我们最近在《阿尔茨海默病杂志：诊断、评估和疾病监测》（2017；9:25-34）中的文章的主题。

主要内容

本文观点针对的是仅根据 CERAD 标准评估神经原纤维缠结斑块而观察到的视觉 [F]flutemetamol PET 图像阅读与组织病理学之间的罕见不匹配，通过评估神经原纤维和弥漫性斑块以及/或脑萎缩可以解决这一问题。

结论

[F]flutemetamol PET 信号主要与神经原纤维斑块病理相对应，但也受到弥漫性斑块的影响。这可以在 AD 痴呆的早期阶段检测到弥漫性淀粉样沉积物，特别是在纹状体中，最常观察到弥漫性淀粉样蛋白。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053f/6015459/a60a24cfdc3b/13195_2018_387_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053f/6015459/a60a24cfdc3b/13195_2018_387_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053f/6015459/a60a24cfdc3b/13195_2018_387_Fig1_HTML.jpg

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