Karunasena Enusha, Sham Jonathan, McMahon Kevin Wyatt, Ahuja Nita
Department of Oncology, GI Clinical Cancer Research and Cancer Immunology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institute, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Department of Surgery, Johns Hopkins Medical Institute, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Surg Oncol Clin N Am. 2018 Jul;27(3):463-475. doi: 10.1016/j.soc.2018.02.004.
The peritoneum protects the intraabdominal organs. This function is exploited by aggressive cancers originating from organs within the abdomen, resulting in peritoneal metastasis. We discuss genomic variants that may lead to peritoneal metastasis from multiple cancers. Peritoneal malignancies are attributed to epithelial-mesenchymal transition. These metastatic lesions harbor similar genetic mutations to the primary tumor yet may manifest clone-specific aberrations that promote propagation. Peritoneal metastasis are increasingly being treated with surgical resection as an adjunct to radiation, chemotherapy, and other biologic therapies. We describe genetic and genomic variances that are predictive markers for metastasis and burgeoning indicators for peritoneal malignancies.
腹膜保护腹腔内器官。起源于腹部器官的侵袭性癌症利用了这一功能，导致腹膜转移。我们讨论了可能导致多种癌症腹膜转移的基因组变异。腹膜恶性肿瘤归因于上皮-间质转化。这些转移性病变具有与原发性肿瘤相似的基因突变，但可能表现出促进增殖的克隆特异性畸变。腹膜转移越来越多地通过手术切除进行治疗，作为放疗、化疗和其他生物疗法的辅助手段。我们描述了作为转移预测标志物和腹膜恶性肿瘤新兴指标的遗传和基因组变异。
