National Research Centre "Kurchatov Institute", Moscow, 123098, Russia; I.M. Sechenov First Moscow State Medical University, Moscow, 119991, Russia; A.V. Shubnikov Institute of Crystallography of Federal Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Russian Academy of Sciences, Moscow, 119333, Russia; Institute of Materials Research and Engineering, A⁎STAR, Singapore, 138634, Singapore.
National Research Centre "Kurchatov Institute", Moscow, 123098, Russia; A.V. Shubnikov Institute of Crystallography of Federal Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Russian Academy of Sciences, Moscow, 119333, Russia.
Colloids Surf B Biointerfaces. 2018 Oct 1;170:312-321. doi: 10.1016/j.colsurfb.2018.06.033. Epub 2018 Jun 19.
Aiming to explore elevated temperatures as a tool for miniaturization of biodegradable polymer multilayer capsules, assembled on spherical vaterite micron- and submicron-sized particles, we subject the shells composed of dextran sulfate (DS) and poly-L-arginine (Parg) to a heat treatment. Changes of the capsule size are studied at various temperatures and ionic strengths of the continuous phase. Unlike some synthetic polymer multilayer shells (their response to heat treatment depends on the number of layers and their arrangement), the biodegradable Parg/DS capsules exhibit size reduction and profound compaction regardless of their initial size, number of polymer layers and polymer layer sequence. The capsule response to heat is stable at ionic strengths of the continuous phase not exceeding 0.1 M NaCl.
为了探索高温作为一种将生物降解聚合物多层胶囊微型化的工具，我们将组装在球形球霰石微米和亚微米大小颗粒上的胶囊进行热处理。在不同的温度和连续相离子强度下研究壳层的尺寸变化。与一些合成聚合物多层壳层不同（它们对热处理的响应取决于层的数量和排列方式），生物降解的 Parg/DS 胶囊无论其初始尺寸、聚合物层数和聚合物层序列如何，都会发生尺寸减小和严重的压实。胶囊对热的响应在连续相的离子强度不超过 0.1 M NaCl 时是稳定的。
