Singh Alok, Srivastava Anand Narain, Akhtar Salman, Siddiqui Mohammad Haris, Singh Pooja, Kumar Vijay
Department of Pathology, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.
Department of Bioengineering, Integral University, Lucknow, Uttar Pradesh, India.
Natl J Maxillofac Surg. 2018 Jan-Jun;9(1):8-13. doi: 10.4103/njms.NJMS_60_17.
Squamous cell carcinoma of oral cavity is one of the most common cancers of Indian subcontinent with the 5-year survival rate of 50% despite the recent advances in the treatment. The aim of the present study was to study cancer stem cell markers CD133 and Oct-4 in oral squamous cell carcinoma (OSCC) patients and their correlation with clinicopathological variables.
This was a prospective study which included 50 cases of histopathologically proven squamous cell carcinoma of oral cavity. Expression of CD133 and Oct-4 was evaluated by immunohistochemistry (IHC) and their expression was correlated with various clinicopathological and demographic parameters.
CD133 expression was seen in 20.6% cases of clinical Stage I-II and in 79.4% of clinical stage of III-IV OSCC patients, the difference being statistically significant with the = 0.048. There was no statistically significant association between CD133 expression and any other clinicopathological or demographic variable. Oct-4 was expressed only in one case.
CD133 expression was significantly seen higher in Stage III-IV tumors, the stem cells may be responsible for the aggressiveness of the OSCCs and these stem cells can be potential prognostic markers and targets for the future targeted therapy.
口腔鳞状细胞癌是印度次大陆最常见的癌症之一，尽管近年来治疗方法有所进步，但其5年生存率仍为50%。本研究的目的是研究口腔鳞状细胞癌（OSCC）患者中癌症干细胞标志物CD133和Oct-4及其与临床病理变量的相关性。
这是一项前瞻性研究，纳入50例经组织病理学证实的口腔鳞状细胞癌病例。通过免疫组织化学（IHC）评估CD133和Oct-4的表达，并将其表达与各种临床病理和人口统计学参数相关联。
在临床I-II期病例中，20.6%的病例可见CD133表达，而在III-IV期OSCC患者中，79.4%的病例可见CD133表达，差异具有统计学意义（P = 0.048）。CD133表达与任何其他临床病理或人口统计学变量之间均无统计学意义的关联。Oct-4仅在1例中表达。
CD133表达在III-IV期肿瘤中显著更高，干细胞可能是OSCC侵袭性的原因，这些干细胞可能是潜在的预后标志物和未来靶向治疗的靶点。
