Univ. Lille, CNRS, Central Lille, ISEN, Univ. Valenciennes, UMR 8520, IEMN, F-59000 Lille, France; Iasi Plasma Advanced Research Center (IPARC), Faculty of Physics, Alexandru Ioan Cuza University of Iasi, Bd. Carol I no. 11, Iasi, 700506, Romania.
Univ. Lille, CNRS, Central Lille, ISEN, Univ. Valenciennes, UMR 8520, IEMN, F-59000 Lille, France.
Colloids Surf B Biointerfaces. 2018 Oct 1;170:347-354. doi: 10.1016/j.colsurfb.2018.06.040. Epub 2018 Jun 19.
In the last years, carbon-based nanomaterials have attracted considerable attention in a wide range of fields, particularly in biomedicine, owing to their remarkable photo-physical and chemical properties. In this study, we demonstrate that amine-terminated carbon dots (CDs-NH) functionalized with ampicillin (AMP) offer a new perspective for antibacterial treatment. The amine-functionalized carbon dots were used as a carrier for immobilization and delivery of ampicillin (CDs-AMP) and as a visible light-triggered antibacterial material. Additionally, AMP immobilization on the CDs-NH surface improves its stability in solution as compared to free AMP. The AMP conjugated CDs platform combines the antibacterial function of AMP and conserves the intrinsic theranostic properties of CDs-NH. Therefore, the AMP immobilized onto CDs-NH surface together with the generation of moderate quantities of reactive oxygen species under visible light illumination are very effective to inactivate the growth of Escherichia coli.
在过去的几年中，由于其显著的光物理和化学性质，基于碳的纳米材料在广泛的领域引起了相当大的关注，特别是在生物医学领域。在这项研究中，我们证明了用氨苄青霉素（AMP）功能化的末端胺基化的碳点（CDs-NH）为抗菌治疗提供了新的视角。胺功能化的碳点被用作固定和输送氨苄青霉素（CDs-AMP）的载体，并且作为可见光触发的抗菌材料。此外，与游离的 AMP 相比，AMP 在 CDs-NH 表面的固定提高了其在溶液中的稳定性。AMP 共轭的 CDs 平台结合了 AMP 的抗菌功能，并保留了 CDs-NH 的固有治疗特性。因此，在可见光照射下，AMP 固定在 CDs-NH 表面上并产生适量的活性氧，这对于灭活大肠杆菌的生长非常有效。
