Department of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, P.O. Box 41, FI-00014 Helsinki, Finland.
Department of Oral and Maxillofacial Diseases, Helsinki University Hospital, P.O. Box 670, FI-00029 HUS, Finland.
Int J Environ Res Public Health. 2018 Jun 25;15(7):1324. doi: 10.3390/ijerph15071324.
The aim of this study was to investigate if a developmental enamel defect known as Molar-Incisor Hypomineralization (MIH) is associated with dental caries. Socioeconomic status (SES) was examined as a confounding factor between caries and MIH. In this cross-sectional study, 636 children, aged 8 to 13 years, from three towns (two rural areas and one urban area) in Finland were examined for MIH in line with the criteria of the European Academy of Paediatric Dentistry. Caries status for permanent teeth was recorded as decayed, missing and filled teeth (DMFT). Caries experience (DMFT > 0) in the first permanent molars (FPMs) was set as an outcome. SES was determined using a questionnaire completed by parents. The prevalence of MIH was 18.1%. The mean DMFT in FPMs for children with MIH was higher than for their peers, 1.03 ± 1.25 vs. 0.32 ± 0.80 ( = 0.000, Mann-Whitney U test). In a multivariate analysis using the generalized linear mixed model where locality, SES, age and MIH were taken into account as caries risk indicators, MIH was the strongest risk indicator of caries in FPMs (Odds Ratio: 6.60, 95% Confidence Interval: 3.83⁻11.39, = 0.000). According to the study results, children with MIH have a higher risk for dental caries than children without MIH.
本研究旨在探讨一种称为磨牙-切牙釉质发育不全(MIH)的发育性牙釉质缺陷是否与龋齿有关。社会经济地位(SES)被视为龋齿和 MIH 之间的混杂因素进行了检查。在这项横断面研究中,对来自芬兰三个城镇(两个农村地区和一个城市地区)的 636 名 8 至 13 岁的儿童进行了 MIH 检查,其标准符合欧洲儿童牙科学会的标准。恒牙龋齿状况记录为龋失补牙数(DMFT)。第一恒磨牙(FPM)中 DMFT>0 的龋齿经历被设定为结局。SES 通过父母填写的问卷确定。MIH 的患病率为 18.1%。有 MIH 的儿童 FPM 的平均 DMFT 高于同龄人,分别为 1.03 ± 1.25 和 0.32 ± 0.80(=0.000,Mann-Whitney U 检验)。在考虑局部性、SES、年龄和 MIH 作为龋齿风险指标的广义线性混合模型的多变量分析中,MIH 是 FPM 龋齿最强的风险指标(优势比:6.60,95%置信区间:3.83⁻11.39,=0.000)。根据研究结果,有 MIH 的儿童比没有 MIH 的儿童患龋齿的风险更高。