Dangi Arun Kumar, Sharma Babita, Khangwal Ishu, Shukla Pratyoosh
Enzyme Technology and Protein Bioinformatics Laboratory, Department of Microbiology, Maharshi Dayanand University, Rohtak, Haryana, 124001, India.
Mol Biotechnol. 2018 Aug;60(8):636-650. doi: 10.1007/s12033-018-0100-9.
Plants are continually facing biotic and abiotic stresses, and hence, they need to respond and adapt to survive. Plant response during multiple and combined biotic and abiotic stresses is highly complex and varied than the individual stress. These stresses resulted alteration of plant behavior through regulating the levels of microRNA, heat shock proteins, epigenetic variations. These variations can cause many adverse effects on the growth and development of the plant. Further, in natural conditions, several abiotic stresses causing factors make the plant more susceptible to pathogens infections and vice-versa. A very intricate and multifaceted interactions of various biomolecules are involved in metabolic pathways that can direct towards a cross-tolerance and improvement of plant's defence system. Systems biology approach plays a significant role in the investigation of these molecular interactions. The valuable information obtained by systems biology will help to develop stress-resistant plant varieties against multiple stresses. Thus, this review aims to decipher various multilevel interactions at the molecular level under combinatorial biotic and abiotic stresses and the role of systems biology to understand these molecular interactions.
植物不断面临生物和非生物胁迫，因此，它们需要做出反应并适应以生存。与单一胁迫相比，植物在多种生物和非生物胁迫组合下的反应高度复杂且多样。这些胁迫通过调节微小RNA、热休克蛋白的水平以及表观遗传变异导致植物行为的改变。这些变异会对植物的生长发育产生许多不利影响。此外，在自然条件下，几种非生物胁迫成因会使植物更容易受到病原体感染，反之亦然。各种生物分子之间非常复杂且多方面的相互作用参与了代谢途径，这些途径可以导向交叉耐受性和植物防御系统的改善。系统生物学方法在研究这些分子相互作用中发挥着重要作用。通过系统生物学获得的有价值信息将有助于培育抗多种胁迫的植物品种。因此，本综述旨在解读组合生物和非生物胁迫下分子水平上的各种多层次相互作用以及系统生物学在理解这些分子相互作用中的作用。
