Stylianakis Anthea A, Harmon-Jones Sylvia K, Richardson Rick, Baker Kathryn D
School of Psychology, UNSW Sydney, Sydney, New South Wales, Australia.
Dev Psychobiol. 2018 Nov;60(7):805-813. doi: 10.1002/dev.21750. Epub 2018 Jun 25.
Adolescence is thought of as a stress-sensitive developmental period. While many studies have compared adolescent responses to stress relative to that of adults, a growing body of work has examined stress responses in juveniles. Here we investigated if a chronic stressor has a differential effect on spatial memory in rats depending on whether it occurs during adolescence or the juvenile period. Male rats were exposed to the stress hormone corticosterone (Cort) in their drinking water, a vehicle control (2.5% ethanol), or water, for 7 days before being tested on a novel Object/Place task 6 days or 6 weeks later. Exposure to Cort or ethanol at either age impaired spatial memory at the 6-day test. The ethanol induced impairment was attenuated 6 weeks later. However, rats given Cort during adolescence, but not the juvenile period, were still impaired. Together, these results suggest that adolescence is indeed a stress-sensitive period.
青春期被认为是一个对压力敏感的发育阶段。虽然许多研究比较了青少年与成年人对压力的反应，但越来越多的研究工作开始关注幼年动物的应激反应。在这里，我们研究了慢性应激源对大鼠空间记忆的影响是否因发生在青春期还是幼年时期而有所不同。雄性大鼠在饮用水中接触应激激素皮质酮（Cort）、载体对照（2.5%乙醇）或水，持续7天，然后在6天或6周后进行新物体/位置任务测试。在两个年龄段接触Cort或乙醇都会在6天测试时损害空间记忆。乙醇诱导的损伤在6周后有所减轻。然而，青春期而非幼年时期接触Cort的大鼠仍然存在记忆损伤。总之，这些结果表明青春期确实是一个对压力敏感的时期。
