Lafosse Edouard, Martínez-Albert Noelia, Wolffsohn James S W, Cerviño Alejandro, García-Lázaro Santiago
Department of Optics & Optometry & Vision Sciences (E.L., N.M.-A., A.C., S.G.-L.), Optometry Research Group, University of Valencia, Valencia, Spain; and Ophthalmic Research Group (E.L., J.S.W.W.), School of Life and Health Sciences, Aston University. Birmingham, United Kingdom.
Eye Contact Lens. 2019 Jan;45(1):40-45. doi: 10.1097/ICL.0000000000000514.
To investigate the ocular surface of an aged population wearing a daily disposable contact lens (CL) over their 1st day of wear.
Forty eyes from 40 presbyopic subjects were fitted a daily CL (Delefilcon A). Tear osmolarity, tear meniscus area (TMA), and ocular surface aberrations (total higher-order root mean square [RMS]) were assessed at baseline (t0), at 20 min (t1) and after 8 hr (t2) of wear. Fluorescein corneal and conjunctival staining and tear breakup time (TBUT) were performed at t0 and t2.
No statistically significant changes were found between t0, t1, and t2 for TMA and between t0 and t2 for fluorescein corneal and conjunctival staining. Tear breakup time worsened by the end of the day from 10.4±0.4 sec t0 to 9.0±0.3 sec t2 (P<0.05). Osmolarity showed significant changes between t0 306.9±2.3 mOsm/L and t1 312.4±2.4 mOsmol/L (P=0.02) but returned to baseline values at 8 hr (310.40±2.26 mOsm/L; P=0.09). Total higher-order RMS showed significant changes between t0 0.38±0.02 μm and t1 0.61±0.04 μm (P≤0.001) and between t0 and t2 0.64±0.41 μm (P≤0.001).
Delefilcon A may induce measures changes (osmolarity and TBUT values) in a presbyopic population; however, TMA and vital staining were maintained at the baseline level over the day.
研究老年人群在佩戴日抛型隐形眼镜的第一天其眼表情况。
为40名老花眼受试者的40只眼睛佩戴日抛型隐形眼镜（Delefilcon A）。在佩戴前（t0）、佩戴20分钟后（t1）和佩戴8小时后（t2）评估泪液渗透压、泪膜弯月面面积（TMA）和眼表像差（总高阶均方根[RMS]）。在t0和t2时进行荧光素角膜和结膜染色以及泪膜破裂时间（TBUT）检查。
TMA在t0、t1和t2之间以及荧光素角膜和结膜染色在t0和t2之间均未发现有统计学意义的变化。泪膜破裂时间在一天结束时从t0的10.4±0.4秒恶化至t2的9.0±0.3秒（P<0.05）。渗透压在t0（306.9±2.3 mOsm/L）和t1（312.4±2.4 mOsmol/L）之间有显著变化（P=0.02），但在8小时时恢复到基线值（310.40±2.26 mOsm/L；P=0.09）。总高阶RMS在t0（0.38±0.02μm）和t1（0.61±0.04μm）之间有显著变化（P≤0.001），在t0和t2（0.64±0.41μm）之间也有显著变化（P≤0.001）。
Delefilcon A可能会在老花眼人群中引起一些指标变化（渗透压和TBUT值）；然而，TMA和活体染色在一天中维持在基线水平。
