Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan.
Department of Pathology, E- Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Int J Med Sci. 2023 Aug 6;20(9):1235-1239. doi: 10.7150/ijms.80488. eCollection 2023.
Aberrant expression of UNC13C (Unc-13 Homolog C) has been observed during the progression of oral squamous cell carcinoma. However, the expression pattern and clinical relevance of UNC13C in Hepatocellular carcinoma (HCC) remain to be elucidated. The purpose of this study is to examine UNC13C expression in HCC and explore its role in clinicopathological factor or prognosis in HCC. Two hundred and sixty-five patients diagnosed with HCC were included in the present study. The expression of UNC13C in HCC tissues was analyzed by immunohistochemistry analysis. The relationship between UNC13C protein and clinicopathological characteristics in HCC was investigated. Moreover, the high expression of UNC13C was significantly correlated with T stage, AJCC stage and overall survival rates. Cox regression analysis identified UNC13C as an independent prognostic indicator for HCC patients. UNC13C might be a prognostic biomarker and therapeutic target in HCC. Further studies with larger sample sets are needed to understand the clinical implications of UNC13C in hepatocellular carcinoma.
UNC13C（Unc-13 同源物 C）的异常表达在口腔鳞状细胞癌的进展过程中观察到。然而，UNC13C 在肝细胞癌（HCC）中的表达模式和临床相关性仍有待阐明。本研究旨在检测 HCC 中 UNC13C 的表达，并探讨其在 HCC 临床病理因素或预后中的作用。本研究纳入了 265 例 HCC 患者。通过免疫组织化学分析检测 HCC 组织中 UNC13C 的表达。研究 UNC13C 蛋白与 HCC 临床病理特征之间的关系。此外，UNC13C 的高表达与 T 分期、AJCC 分期和总生存率显著相关。Cox 回归分析确定 UNC13C 是 HCC 患者的独立预后指标。UNC13C 可能是 HCC 的预后生物标志物和治疗靶点。需要进一步的大样本研究来了解 UNC13C 在肝细胞癌中的临床意义。
