冷冻电镜解析 G 蛋白偶联受体信号转导
Illuminating GPCR Signaling by Cryo-EM.
机构信息
Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India.
Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
出版信息
Trends Cell Biol. 2018 Aug;28(8):591-594. doi: 10.1016/j.tcb.2018.06.002. Epub 2018 Jun 23.
PMID:29945844
Abstract
The wave of resolution revolution in cryo-EM has touched, and made a significant impact on, the structural biology of GPCRs. High-resolution structures of several GPCR-G-protein complexes are now determined by cryo-EM and they illuminate fine structural details of this central macromolecular complex involved in cellular signaling.
摘要
冷冻电镜分辨率革命的浪潮已经触及并对 GPCR 的结构生物学产生了重大影响。现在，通过冷冻电镜已经确定了几个 GPCR-蛋白复合物的高分辨率结构，它们揭示了参与细胞信号转导的这个核心大分子复合物的精细结构细节。
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