Jafari Nedooshan Jamal, Kargar Saeed, Neamatzadeh Hossein, Haghighi Fatemeh, Dehghani Mohammad Abadi Reihaneh, Seddighi Niloofar
Department of General Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Email:
Asian Pac J Cancer Prev. 2017 Apr 1;18(4):1031-1037. doi: 10.22034/APJCP.2017.18.4.1031.
Background: Previously published data on any association of the fat mass and obesity-associated (FTO) gene with breast cancer risk remain inconclusive. Therefore, we conducted the present meta-analysis of links between breast cancer and the FTO rs9939609 polymorphism. Methods: We have conducted a systematic review of the English literature by searching PubMed, Google Scholar and ISI Web of Knowledge databases for studies on associations between the FTO rs9939609 polymorphism and breast cancer risk. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association using fixed- or random-effects model. Results: We included five studies with 1134 cases and 1453 controls. Overall, no significant association between the FTO rs9939609 polymorphism and risk of breast cancer was found. On subgroup analysis by ethnicity, there was still no significant association detected. Conclusions: To our knowledge, this is the first meta-analysis of the FTO rs9939609 polymorphism and risk of breast cancer. However, the present meta-analysis suggested that only there might be a significant association of the CXCL12 rs1801157 polymorphisms with breast cancer risk.
先前发表的关于脂肪量和肥胖相关（FTO）基因与乳腺癌风险之间任何关联的数据尚无定论。因此，我们对乳腺癌与FTO rs9939609多态性之间的联系进行了本次荟萃分析。方法：我们通过检索PubMed、谷歌学术和ISI知识网络数据库，对英文文献进行了系统综述，以查找关于FTO rs9939609多态性与乳腺癌风险之间关联的研究。使用固定效应或随机效应模型计算95%置信区间（CI）的粗比值比（OR），以估计关联强度。结果：我们纳入了五项研究，共1134例病例和1453例对照。总体而言，未发现FTO rs9939609多态性与乳腺癌风险之间存在显著关联。按种族进行亚组分析时，也未检测到显著关联。结论：据我们所知，这是首次对FTO rs9939609多态性与乳腺癌风险进行的荟萃分析。然而，本次荟萃分析表明，仅CXCL12 rs1801157多态性可能与乳腺癌风险存在显著关联。
