Baktash Amoe, Terveer Elisabeth M, Zwittink Romy D, Hornung Bastian V H, Corver Jeroen, Kuijper Ed J, Smits Wiep Klaas
Clinical Microbiology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands.
Center for Microbiome Analyses and Therapeutics, Leiden University Medical Center, Leiden, Netherlands.
Front Microbiol. 2018 Jun 12;9:1242. doi: 10.3389/fmicb.2018.01242. eCollection 2018.
Fecal microbiota transplantation has proven to be an effective treatment for infections with the gram-positive enteropathogen . Despite its effectiveness, the exact mechanisms that underlie its success are largely unclear. In this review, we highlight the pleiotropic effectors that are transferred during fecal microbiota transfer and relate this to the lifecycle. In doing so, we show that it is likely that multiple factors contribute to the elimination of symptoms of infections after fecal microbiota transplantation.
粪菌移植已被证明是治疗革兰氏阳性肠道病原体感染的有效方法。尽管其疗效显著,但其成功背后的确切机制在很大程度上仍不清楚。在本综述中,我们强调了在粪菌移植过程中转移的多效性效应物,并将其与生命周期联系起来。通过这样做,我们表明,粪菌移植后感染症状的消除可能是多种因素共同作用的结果。