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粪便微生物群移植治疗感染成功的机制性见解

Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Infections.

作者信息

Baktash Amoe, Terveer Elisabeth M, Zwittink Romy D, Hornung Bastian V H, Corver Jeroen, Kuijper Ed J, Smits Wiep Klaas

机构信息

Clinical Microbiology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands.

Center for Microbiome Analyses and Therapeutics, Leiden University Medical Center, Leiden, Netherlands.

出版信息

Front Microbiol. 2018 Jun 12;9:1242. doi: 10.3389/fmicb.2018.01242. eCollection 2018.

Abstract

Fecal microbiota transplantation has proven to be an effective treatment for infections with the gram-positive enteropathogen . Despite its effectiveness, the exact mechanisms that underlie its success are largely unclear. In this review, we highlight the pleiotropic effectors that are transferred during fecal microbiota transfer and relate this to the lifecycle. In doing so, we show that it is likely that multiple factors contribute to the elimination of symptoms of infections after fecal microbiota transplantation.

摘要

粪菌移植已被证明是治疗革兰氏阳性肠道病原体感染的有效方法。尽管其疗效显著,但其成功背后的确切机制在很大程度上仍不清楚。在本综述中,我们强调了在粪菌移植过程中转移的多效性效应物,并将其与生命周期联系起来。通过这样做,我们表明,粪菌移植后感染症状的消除可能是多种因素共同作用的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/610e/6005852/556571e62de5/fmicb-09-01242-g001.jpg

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