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Ceragenin CSA13 Reduces Clostridium difficile Infection in Mice by Modulating the Intestinal Microbiome and Metabolites.短链 Ceragenin CSA13 通过调节肠道微生物组和代谢物减少小鼠艰难梭菌感染。
Gastroenterology. 2018 May;154(6):1737-1750. doi: 10.1053/j.gastro.2018.01.026. Epub 2018 Jan 31.
2
Colonizes Alternative Nutrient Niches during Infection across Distinct Murine Gut Microbiomes.在感染过程中,跨不同小鼠肠道微生物群定殖于替代性营养生态位。
mSystems. 2017 Jul 25;2(4). doi: 10.1128/mSystems.00063-17. eCollection 2017 Jul-Aug.
3
Clostridium difficile Toxin Biology.艰难梭菌毒素生物学。
Annu Rev Microbiol. 2017 Sep 8;71:281-307. doi: 10.1146/annurev-micro-090816-093458. Epub 2017 Jun 28.
4
How we become ill: Investigating emergent properties of biological systems could help to better understand the pathology of diseases.我们如何生病:研究生物系统的涌现特性有助于更好地理解疾病的病理学。
EMBO Rep. 2017 Apr;18(4):515-518. doi: 10.15252/embr.201743948. Epub 2017 Feb 27.
5
Functional Intestinal Bile Acid 7α-Dehydroxylation by Associated with Protection from Infection in a Gnotobiotic Mouse Model.在悉生小鼠模型中,功能性肠道胆汁酸7α-脱羟基作用与抵御感染相关。
Front Cell Infect Microbiol. 2016 Dec 20;6:191. doi: 10.3389/fcimb.2016.00191. eCollection 2016.
6
Ursodeoxycholic Acid Inhibits Clostridium difficile Spore Germination and Vegetative Growth, and Prevents the Recurrence of Ileal Pouchitis Associated With the Infection.熊去氧胆酸抑制艰难梭菌孢子萌发和营养生长,并预防与该感染相关的回肠储袋炎复发。
J Clin Gastroenterol. 2016 Sep;50(8):624-30. doi: 10.1097/MCG.0000000000000427.
7
Bactericidal Activity of Ceragenin CSA-13 in Cell Culture and in an Animal Model of Peritoneal Infection.杀菌肽CSA-13在细胞培养及腹膜感染动物模型中的杀菌活性
Antimicrob Agents Chemother. 2015 Oct;59(10):6274-82. doi: 10.1128/AAC.00653-15. Epub 2015 Jul 27.
8
Fecal Microbiota Transplantation Eliminates Clostridium difficile in a Murine Model of Relapsing Disease.粪便微生物群移植可消除复发性疾病小鼠模型中的艰难梭菌。
Infect Immun. 2015 Oct;83(10):3838-46. doi: 10.1128/IAI.00459-15. Epub 2015 Jul 13.
9
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile.精准微生物群重建可恢复胆汁酸介导的对艰难梭菌的抗性。
Nature. 2015 Jan 8;517(7533):205-8. doi: 10.1038/nature13828. Epub 2014 Oct 22.
10
Clostridium difficile and the microbiota.艰难梭菌与微生物群
J Clin Invest. 2014 Oct;124(10):4182-9. doi: 10.1172/JCI72336. Epub 2014 Jul 18.

Clostridium difficile Infection and the Tangled Web of Interactions Among Host, Pathogen, and Microbiota.

作者信息

Seekatz Anna Maria, Young Vincent Bensan

机构信息

University of Michigan Medical School, Ann Arbor, Michigan.

University of Michigan Medical School, Ann Arbor, Michigan.

出版信息

Gastroenterology. 2018 May;154(6):1573-1576. doi: 10.1053/j.gastro.2018.03.036. Epub 2018 Mar 28.

DOI:10.1053/j.gastro.2018.03.036
PMID:29601830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12123524/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7bb/12123524/0a552b9d3c07/nihms-2080777-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7bb/12123524/0a552b9d3c07/nihms-2080777-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7bb/12123524/0a552b9d3c07/nihms-2080777-f0001.jpg