Evans Anna, Malvar Jemily, Garretson Cassie, Pedroja Kolovos Eliza, Baron Nelson Mary
1 Children's Hospital Los Angeles, Los Angeles, CA, USA.
2 UCLA Medical Center, Los Angeles, CA, USA.
J Pediatr Oncol Nurs. 2018 Nov/Dec;35(6):392-398. doi: 10.1177/1043454218782133. Epub 2018 Jun 27.
Chemotherapy-induced nausea can be distressing and difficult to manage in children with cancer. The purpose of this study was to investigate the utility of ginger aromatherapy in relieving chemotherapy-induced nausea in children with cancer.
This randomized, double-blind, placebo-controlled study of 49 children with cancer explored whether inhalation of the aroma of essential oil of ginger during chemotherapy decreased nausea compared with a placebo (water) or control (Johnson's baby shampoo) measured by prechemotherapy and postchemotherapy assessment with the Pediatric Nausea Assessment Tool (PeNAT).
While well received, well tolerated, nontoxic, and noninvasive, ginger aromatherapy did not significantly decrease nausea in patients enrolled in this study. Among 21 patients who indicated feeling nausea prechemotherapy, 67% reported improvement, 5% worsening, and 28% no change in their postinfusion PeNAT score. We failed to detect a statistical significant difference in the change in PeNAT scores among the three groups.
化疗引起的恶心可能会给患癌儿童带来痛苦且难以控制。本研究的目的是探讨姜香薰疗法在缓解患癌儿童化疗引起的恶心方面的效用。
这项针对49名患癌儿童的随机、双盲、安慰剂对照研究，通过化疗前和化疗后使用儿童恶心评估工具（PeNAT）进行评估，探究化疗期间吸入姜精油香气与安慰剂（水）或对照物（强生婴儿洗发水）相比，是否能减轻恶心症状。
尽管姜香薰疗法受到好评、耐受性良好、无毒且无创，但在本研究的患者中，它并未显著减轻恶心症状。在化疗前表示感到恶心的21名患者中，67%报告输注后PeNAT评分有所改善，5%恶化，28%无变化。我们未能检测到三组之间PeNAT评分变化的统计学显著差异。
