Payne M R, Howie P W, McNeilly A S, Cooper W, Marnie M, Kidd L
Br Med J (Clin Res Ed). 1985 Aug 31;291(6495):559-61. doi: 10.1136/bmj.291.6495.559.
A progestogen (norethisterone) and a dopamine antagonist (sulpiride) were given alone and in combination to volunteers to examine their effects on excretion of ovarian steroids. Compared with non-treatment cycles (n = 15), contraception with a progestogen alone (n = 10) was associated with increased excretion of oestrone and partial suppression of excretion of pregnanediol, suggesting partial luteinization of unruptured follicles. By contrast, the combination of norethisterone and sulpiride (n = 9) suppressed both ovarian steroids to basal values, the suppression being even greater than with sulpiride alone (n = 5). These results suggest that a combination of a progestogen with a dopamine antagonist might have a role in contraception.
将孕激素（炔诺酮）和多巴胺拮抗剂（舒必利）单独及联合给予志愿者，以研究它们对卵巢甾体激素排泄的影响。与未治疗周期（n = 15）相比，单独使用孕激素避孕（n = 10）会导致雌酮排泄增加，孕二醇排泄部分受抑制，提示未破裂卵泡部分黄素化。相比之下，炔诺酮和舒必利联合使用（n = 9）可将两种卵巢甾体激素都抑制至基础值，这种抑制作用甚至比单独使用舒必利（n = 5）时更强。这些结果表明，孕激素与多巴胺拮抗剂联合使用可能在避孕方面发挥作用。
