催乳素对低剂量舒必利的反应。
Prolactin response to low dose sulpiride.
作者信息
McMurdo M E, Howie P W, Lewis M, Marnie M, McEwen J, McNeilly A S
出版信息
Br J Clin Pharmacol. 1987 Aug;24(2):133-7. doi: 10.1111/j.1365-2125.1987.tb03153.x.
Abstract
1 Prolactin levels in response to sulpiride were studied in healthy volunteers. 2 Oral doses of 1 mg-50 mg sulpiride or placebo were given. 3 A 3 mg sulpiride dose produced similar levels to those achieved with both 10 mg and 50 mg. 4 Circadian effects were studied showing no significant differences in the prolactin response to sulpiride. 5 Acute or chronic responses showed an attenuation with chronic sulpiride treatment to 50% of the peak levels attained with acute treatment. 6 These results indicate that sulpiride retains its potent ability to produce prolactin release even at the low doses studied here.
摘要
- 在健康志愿者中研究了舒必利对催乳素水平的影响。2. 口服给予1毫克至50毫克的舒必利或安慰剂。3. 3毫克舒必利剂量产生的水平与10毫克和50毫克所达到的水平相似。4. 研究了昼夜节律效应，结果显示舒必利对催乳素的反应无显著差异。5. 急性或慢性反应表明，慢性舒必利治疗使反应减弱至急性治疗所达到峰值水平的50%。6. 这些结果表明，即使在此处研究的低剂量下，舒必利仍保持其产生催乳素释放的强大能力。
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本文引用的文献
1
Prolactin responsiveness to repeated decremental doses of sulpiride.催乳素对重复递减剂量舒必利的反应性。
Horm Metab Res. 1981 Aug;13(8):454-5. doi: 10.1055/s-2007-1019299.
2
Sulpiride improves inadequate lactation.舒必利可改善泌乳不足。
Br Med J (Clin Res Ed). 1982 Jul 24;285(6337):249-51. doi: 10.1136/bmj.285.6337.249.
3
Unresponsiveness of prolactin to repeated injection of sulpiride in man.人催乳素对重复注射舒必利无反应。
Eur J Clin Pharmacol. 1983;25(2):275-7. doi: 10.1007/BF00543803.
4
Oral contraceptive agents do not affect serum prolactin in normal women.口服避孕药对正常女性的血清催乳素水平无影响。
Clin Endocrinol (Oxf). 1984 Apr;20(4):427-34. doi: 10.1111/j.1365-2265.1984.tb03438.x.
5
Circadian periodicity of serum prolactin concentration in man.男性血清催乳素浓度的昼夜节律性。
Br Med J. 1972 Sep 2;3(5826):561-2. doi: 10.1136/bmj.3.5826.561.
6
Sulpiride and the potentiation of progestogen only contraception.舒必利与仅含孕激素避孕药的增效作用
Br Med J (Clin Res Ed). 1985 Aug 31;291(6495):559-61. doi: 10.1136/bmj.291.6495.559.
7
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8
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