Institute of Neuroimmunology, Slovak Academy of Sciences, Centre of Excellence for Alzheimer's Disease and Related Disorders, Dúbravská cesta 9, 845 10, Bratislava, Slovak Republic.
Axon Neuroscience R&D Services SE, Dvořákovo nábrežie 10, Bratislava, Slovak Republic.
Cell Mol Neurobiol. 2018 Aug;38(6):1207-1214. doi: 10.1007/s10571-018-0598-1. Epub 2018 Jun 13.
Despite years of research, Alzheimer's disease (AD) remains incurable and thus poses a major health challenge in coming years. This neurodegenerative disease belongs to a heterogeneous group of human tauopathies, characterized by the extracellular deposition of beta amyloid-Aβ and intracellular accumulation of tau protein in neuronal and glial cells, whereby tau pathology best correlates with disease progression. For decades, several disease-modifying agents were brought to clinical studies with promising efficacy in preclinical trials; however, all of the subsequent clinical trials failed. Therefore, the pursuit for therapeutic agents for the treatment of AD and other tauopathies still continue. Recent evidences show previously unidentified role of peripheral immune system in regulating the inflammatory status of the brain, mainly the dendritic cells. A decrease in functionality and count of dendritic cells has been observed in Alzheimer's disease. Here, we discuss a potential role of dendritic cell-based vaccines as therapeutic approach in ameliorating disease pathogenesis in AD and other tauopathies.
尽管经过多年的研究，阿尔茨海默病（AD）仍然无法治愈，因此在未来几年将构成重大健康挑战。这种神经退行性疾病属于人类 tau 病的异质组，其特征是β淀粉样蛋白-Aβ在细胞外沉积和tau 蛋白在神经元和神经胶质细胞内积累，其中 tau 病理学与疾病进展相关性最好。几十年来，有几种疾病修饰剂被带到临床研究中，在临床前试验中显示出有希望的疗效；然而，随后的所有临床试验都失败了。因此，人们仍在继续寻找治疗 AD 和其他 tau 病的治疗剂。最近的证据表明，外周免疫系统在调节大脑炎症状态方面具有以前未被识别的作用，主要是树突状细胞。在阿尔茨海默病中观察到树突状细胞的功能和数量下降。在这里，我们讨论了基于树突状细胞的疫苗作为治疗 AD 和其他 tau 病的一种治疗方法的潜在作用，以改善疾病发病机制。
