Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo Mártires da Pátria 130, 1169-056 Lisboa, Portugal.
Unidade de Investigação em Patobiologia Molecular do Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Prof. Lima Basto, 1099-023 Lisboa, Portugal.
Int J Mol Sci. 2018 Jun 26;19(7):1882. doi: 10.3390/ijms19071882.
Glutathione (GSH) has several roles in a cell, such as a reactive oxygen species (ROS) scavenger, an intervenient in xenobiotics metabolism and a reservoir of cysteine. All of these activities are important in the maintenance of normal cells homeostasis but can also constitute an advantage for cancer cells, allowing disease progression and resistance to therapy. Ovarian cancer is the major cause of death from gynaecologic disease and the second most common gynaecologic malignancy worldwide. In over 50 years, the overall survival of patients diagnosed with epithelial ovarian cancer has not changed, regardless of the efforts concerning early detection, radical surgery and new therapeutic approaches. Late diagnosis and resistance to therapy are the main causes of this outcome, and GSH is profoundly associated with chemoresistance to platinum salts, which, together with taxane-based chemotherapy and surgery, are the main therapy strategies in ovarian cancer treatment. Herein, we present some insights into the role of GSH in the poor prognosis of ovarian cancer, and also point out how some strategies underlying the dependence of ovarian cancer cells on GSH can be further used to improve the effectiveness of therapy.
谷胱甘肽 (GSH) 在细胞中具有多种作用，例如活性氧 (ROS) 清除剂、参与外来物质代谢和半胱氨酸储备库。所有这些活动对于维持正常细胞的内稳态都很重要，但也可能成为癌细胞的优势，从而促进疾病的进展并对治疗产生耐药性。卵巢癌是妇科疾病死亡的主要原因，也是全球第二常见的妇科恶性肿瘤。尽管在早期检测、根治性手术和新的治疗方法方面做出了努力，但在过去的 50 多年中，被诊断为上皮性卵巢癌的患者的总体生存率并未改变。晚期诊断和治疗耐药性是导致这种结果的主要原因，而 GSH 与铂盐的化疗耐药性密切相关，铂盐联合紫杉醇类化疗和手术是卵巢癌治疗的主要策略。在此，我们介绍了 GSH 在上皮性卵巢癌不良预后中的作用，并指出了卵巢癌细胞对 GSH 的依赖性的一些潜在策略如何进一步用于提高治疗效果。
