Gabel Kelsey, Hoddy Kristin K, Haggerty Nicole, Song Jeehee, Kroeger Cynthia M, Trepanowski John F, Panda Satchidananda, Varady Krista A
Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
School of Public Health, Indiana University, Bloomington, IN, USA.
Nutr Healthy Aging. 2018 Jun 15;4(4):345-353. doi: 10.3233/NHA-170036.
Time restricted feeding decreases energy intake without calorie counting and may be a viable option for weight loss. However, the effect of this diet on body weight in obese subjects has never been examined.
This study investigated the effects of 8-h time restricted feeding on body weight and metabolic disease risk factors in obese adults.
Obese subjects ( = 23) participated in an 8-h time restricted feeding intervention (ad libitum feeding between 10:00 to 18:00 h, water fasting between 18:00 to 10:00 h) for 12 weeks. Weight loss and other outcomes were compared to a matched historical control group ( = 23).
Body weight and energy intake decreased in the time restricted group (-2.6% ± 0.5; -341 ± 53 kcal/d) relative to controls over 12 weeks ( < 0.05). Systolic blood pressure decreased in the time restricted feeding group (-7 ± 2 mm Hg) versus controls ( < 0.05). Fat mass, lean mass, visceral fat mass, diastolic blood pressure, LDL cholesterol, HDL cholesterol, triglycerides, fasting glucose, fasting insulin, HOMA-IR, and homocysteine were not significantly different from controls after 12 weeks (no group×time interaction).
These findings suggest that 8-h time restricted feeding produces mild caloric restriction and weight loss, without calorie counting. It may also offer clinical benefits by reducing blood pressure.
限时进食可在不计算卡路里的情况下减少能量摄入，可能是一种可行的减肥方法。然而，这种饮食方式对肥胖受试者体重的影响尚未得到研究。
本研究调查了8小时限时进食对肥胖成年人的体重和代谢疾病风险因素的影响。
肥胖受试者（n = 23）参加了为期12周的8小时限时进食干预（10:00至18:00自由进食，18:00至10:00禁食水）。将体重减轻和其他结果与匹配的历史对照组（n = 23）进行比较。
在12周内，限时进食组的体重和能量摄入相对于对照组有所下降（-2.6% ± 0.5；-341 ± 53千卡/天）（P < 0.05）。限时进食组的收缩压相对于对照组有所下降（-7 ± 2毫米汞柱）（P < 0.05）。12周后，脂肪量、瘦体重、内脏脂肪量、舒张压、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、空腹血糖、空腹胰岛素、HOMA-IR和同型半胱氨酸与对照组相比无显著差异（无组×时间交互作用）。
这些发现表明，8小时限时进食可在不计算卡路里的情况下产生轻度热量限制并减轻体重。它还可能通过降低血压带来临床益处。
