Yüzbaşıoğlu Merve, Özder Aclan
Department of Family Medicine, Şişli Etfal Training and Research Hospital, Istanbul, Turkey. Email:
Department of Family Medicine, Bezmialem Vakıf University Faculty of Medicine, Istanbul, Turkey.
Asia Pac J Clin Nutr. 2025 Aug;34(4):589-595. doi: 10.6133/apjcn.202508_34(4).0010.
Obesity and obesity-related diseases is increasing worldwide. The widely accepted approach in the dietary treatment of obesity is the calorie-restricted six meal diet; however, alternative approaches are needed. This study aimed to compare time-restricted eating (TRE), a method that can be easily conveyed and applied in overcoming obesity, to six meals diet.
A total of 174 participants aged 18-65, BMI>25 kg/m2 were included, with 88 participants in the time-restricted eating group and 86 participants in the six-meal group. Diet lists with similar calorie, macro counts suitable for their respective groups were prepared. Anthropometric measurements, blood pressure, blood tests were analyzed before the study and at the end of the 8-week.
More weight loss [MD: 1.17 kg, (95% CI: 0.23-2.06), Cohen's d=0.42], higher decrease in BMI [MD: 0.41 kg/m2 (95% CI: -0.77 to -0.06), Cohen's d=0.39] , decrease in waist-to-hip ratio [MD: 0.008 (95% CI: -0.016-0.000), Cohen's d=0.35], decrease in obesity degree [MD: 2.35 (95% CI: -3.99 to -0.70), Cohen's d=0.50] were observed in the time-restricted eating group (p<0.05). In the six meals group, decrease in LDL values was higher compared to the time-restricted eating group [p<0.05, MD:0.23 mmol/L (95% Cl:0.41-15.79), Cohen's d=0.36]. More participants preferred to continue TRE (p<0.001).
TRE resulted in greater weight loss, body fat reduction, and improved metabolic parameters, proving more effective for weight management. The six-meal diet was superior for LDL reduction. Both approaches yielded positive outcomes, with TRE emerging as an alternative weight loss strategy.
肥胖及肥胖相关疾病在全球范围内呈上升趋势。肥胖饮食治疗中广泛接受的方法是限制热量的六餐饮食；然而，需要其他替代方法。本研究旨在将限时进食（TRE），一种易于传授和应用于克服肥胖的方法，与六餐饮食进行比较。
共纳入174名年龄在18 - 65岁、BMI>25 kg/m²的参与者，其中88名参与者在限时进食组，86名参与者在六餐组。为各自组准备了热量、宏量营养素计数相似的饮食清单。在研究开始前和8周结束时分析人体测量指标、血压、血液检测结果。
限时进食组观察到更多的体重减轻[平均差值：1.17 kg，（95%置信区间：0.23 - 2.06），科恩d值 = 0.42]，BMI下降幅度更大[平均差值：0.41 kg/m²（95%置信区间： - 0.77至 - 0.06），科恩d值 = 0.39]，腰臀比下降[平均差值：0.008（95%置信区间： - 0.016 - 0.000），科恩d值 = 0.35]，肥胖程度下降[平均差值：2.35（95%置信区间： - 3.99至 - 0.70），科恩d值 = 0.50]（p<0.05）。在六餐组中，与限时进食组相比，低密度脂蛋白（LDL）值下降幅度更大[p<0.05，平均差值：0.23 mmol/L（95%置信区间：0.41 - 15.79），科恩d值 = 0.36]。更多参与者倾向于继续进行限时进食（p<0.001）。
限时进食导致更多的体重减轻、体脂减少和代谢参数改善，证明对体重管理更有效。六餐饮食在降低LDL方面更具优势。两种方法均产生了积极结果，限时进食成为一种替代的减肥策略。
