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对高危人群进行艾滋病血液学筛查的价值。

The value of haematological screening for AIDS in an at risk population.

作者信息

Weber J N, Walker D, Engelkins H, Bain B, Harris J R

出版信息

Genitourin Med. 1985 Oct;61(5):325-9. doi: 10.1136/sti.61.5.325.

DOI:10.1136/sti.61.5.325
PMID:2995238
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1011847/
Abstract

The haematological variables measured by automated full blood count in matched homosexual and heterosexual men attending a clinic for sexually transmitted diseases (STD) were compared with those of normal controls and patients infected with the human T lymphotropic virus type III (HTLV-III). Homosexual and heterosexual men were statistically identical for all variables, but both differed noticeably from patients with clinical diagnoses of the acquired immune deficiency syndrome (AIDS) or AIDS related disease. A full blood count as a screening test for AIDS is only interpretable in the context of clinical assessment.

摘要

对到性传播疾病（STD）门诊就诊的配对同性恋和异性恋男性，通过自动全血细胞计数所测得的血液学变量，与正常对照以及感染人类嗜T淋巴细胞病毒III型（HTLV-III）的患者进行了比较。同性恋和异性恋男性在所有变量上在统计学上并无差异，但二者均与临床诊断为获得性免疫缺陷综合征（AIDS）或AIDS相关疾病的患者有显著差异。全血细胞计数作为AIDS的筛查试验，只有在临床评估的背景下才可解读。

相似文献

1
The value of haematological screening for AIDS in an at risk population.对高危人群进行艾滋病血液学筛查的价值。
Genitourin Med. 1985 Oct;61(5):325-9. doi: 10.1136/sti.61.5.325.
2
The Vancouver Lymphadenopathy-AIDS Study: 2. Seroepidemiology of HTLV-III antibody.温哥华淋巴结病-艾滋病研究：2. 人类嗜T淋巴细胞病毒III型抗体的血清流行病学
Can Med Assoc J. 1985 Jun 15;132(12):1373-7.
3
Human T-cell lymphotropic virus type III associated disorders. The spectrum in the heterosexual population.人类嗜T细胞病毒III型相关疾病。异性恋人群中的疾病谱。
Arch Intern Med. 1986 Aug;146(8):1501-4.
4
Demonstration of antibodies to human T-lymphotropic retrovirus type III in lymphoadenopathy syndrome patients and in individuals at risk for acquired immune deficiency syndrome (AIDS) in Italy.意大利淋巴结病综合征患者及获得性免疫缺陷综合征（艾滋病）高危个体中抗人类Ⅲ型嗜T淋巴细胞逆转录病毒抗体的检测。
Am J Epidemiol. 1986 Feb;123(2):308-15. doi: 10.1093/oxfordjournals.aje.a114239.
5
Prospective study of cytotoxic T lymphocyte responses to influenza and antibodies to human T lymphotropic virus-III in homosexual men. Selective loss of an influenza-specific, human leukocyte antigen-restricted cytotoxic T lymphocyte response in human T lymphotropic virus-III positive individuals with symptoms of acquired immunodeficiency syndrome and in a patient with acquired immunodeficiency syndrome.对同性恋男性中细胞毒性T淋巴细胞对流感的反应及人类嗜T淋巴细胞病毒III型抗体的前瞻性研究。在患有获得性免疫缺陷综合征症状的人类嗜T淋巴细胞病毒III型阳性个体以及一名获得性免疫缺陷综合征患者中，流感特异性、人类白细胞抗原限制的细胞毒性T淋巴细胞反应选择性丧失。
J Clin Invest. 1985 Oct;76(4):1699-704. doi: 10.1172/JCI112158.
6
Rising prevalence of human T-lymphotropic virus type III (HTLV-III) infection in homosexual men in London.伦敦同性恋男性中人类嗜T淋巴细胞病毒III型（HTLV-III）感染率上升。
Lancet. 1985 Jun 1;1(8440):1261-2. doi: 10.1016/s0140-6736(85)92324-4.
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Antibody to human T cell leukaemia virus type III in Australian homosexual men with lymphadenopathy.澳大利亚患有淋巴结病的同性恋男性体内抗人类III型T细胞白血病病毒抗体。
Med J Aust. 1984 Sep 1;141(5):274-6. doi: 10.5694/j.1326-5377.1984.tb113097.x.
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Serum beta-2 microglobulin levels in homosexual men with AIDS and with persistent, generalized lymphadenopathy.患有艾滋病且伴有持续性全身性淋巴结病的同性恋男性的血清β-2微球蛋白水平
Cancer. 1986 Jun 1;57(11):2190-2. doi: 10.1002/1097-0142(19860601)57:11<2190::aid-cncr2820571118>3.0.co;2-y.
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Clinical findings and serological evidence of HTLV-III infection in homosexual contacts of patients with AIDS and persistent generalised lymphadenopathy in London.伦敦艾滋病患者及持续性全身性淋巴结肿大患者同性恋接触者中HTLV-III感染的临床发现及血清学证据。
Lancet. 1984 Sep 1;2(8401):480-3. doi: 10.1016/s0140-6736(84)92563-7.
10
Factors affecting seropositivity to human T cell lymphotropic virus type III (HTLV-III) or lymphadenopathy associated virus (LAV) and progression of disease in sexual partners of patients with AIDS.影响人类Ⅲ型嗜T细胞病毒（HTLV-III）或淋巴结病相关病毒（LAV）血清阳性及艾滋病患者性伴侣疾病进展的因素。
Genitourin Med. 1986 Jun;62(3):177-80. doi: 10.1136/sti.62.3.177.

本文引用的文献

1
An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction.社区获得性卡氏肺孢子虫肺炎暴发：细胞免疫功能障碍的初始表现。
N Engl J Med. 1981 Dec 10;305(24):1431-8. doi: 10.1056/NEJM198112103052402.
2
Clinical aspects of the acquired immune deficiency syndrome in the United Kingdom.英国获得性免疫缺陷综合征的临床情况
Br J Vener Dis. 1984 Aug;60(4):253-7. doi: 10.1136/sti.60.4.253.
3
Hematologic manifestations in homosexual men with Kaposi's sarcoma.患有卡波西肉瘤的同性恋男性的血液学表现。
Am J Clin Pathol. 1984 Jan;81(1):13-8. doi: 10.1093/ajcp/81.1.13.
4
On the mechanism of thrombocytopenic purpura in sexually active homosexual men.关于性活跃同性恋男性血小板减少性紫癜的发病机制
N Engl J Med. 1984 Sep 6;311(10):635-9. doi: 10.1056/NEJM198409063111004.
5
Acid-labile alpha interferon. A possible preclinical marker for the acquired immunodeficiency syndrome in hemophilia.
N Engl J Med. 1983 Sep 8;309(10):583-6. doi: 10.1056/NEJM198309083091003.
6
Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS.艾滋病患者血清中与人类嗜T淋巴细胞逆转录病毒（HTLV - III）反应的抗体。
Science. 1984 May 4;224(4648):506-8. doi: 10.1126/science.6324345.
7
Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions.男性同性恋者中严重的获得性免疫缺陷，表现为慢性肛周单纯疱疹溃疡性病变。
N Engl J Med. 1981 Dec 10;305(24):1439-44. doi: 10.1056/NEJM198112103052403.
8
Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency.既往健康的同性恋男性中的卡氏肺孢子虫肺炎和黏膜念珠菌病：一种新获得性细胞免疫缺陷的证据。
N Engl J Med. 1981 Dec 10;305(24):1425-31. doi: 10.1056/NEJM198112103052401.
9
Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS.从艾滋病患者和艾滋病前期患者中检测、分离并持续生产细胞病变逆转录病毒（HTLV-III）。
Science. 1984 May 4;224(4648):497-500. doi: 10.1126/science.6200935.
10
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).从一名有获得性免疫缺陷综合征（艾滋病）风险的患者体内分离出一种嗜T淋巴细胞逆转录病毒。
Science. 1983 May 20;220(4599):868-71. doi: 10.1126/science.6189183.