Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.
Department of Growth and Reproduction and EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Acta Paediatr. 2019 Feb;108(2):321-327. doi: 10.1111/apa.14480. Epub 2018 Jul 20.
The aim was to assess the influence of dietary counselling on the pubertal development and hormonal status in healthy adolescents.
We used a subcohort of 193 healthy boys (52%) and girls (48%) from the Special Turku Coronary Risk Factor Intervention Project. Participants were recruited by nurses at the well-baby clinics in Turku Finland in 1990-1992 and randomised into intervention and control groups. Intervention children received low-saturated fat and low-cholesterol dietary counselling initiated at seven months of age. Participants were examined once a year with Tanner staging, anthropometric measurements and serial reproductive hormones from 10 to 19 years of age. In girls, postmenarcheal hormones were not analysed.
Pubertal hormones in boys or girls did not differ between the intervention and control groups. However, we observed slight differences in pubertal progression by Tanner staging and in anthropometric parameters. The intervention boys progressed faster to G4 (p = 0.008), G5 (p = 0.008) and P5 (p = 0.03). The intervention boys were taller than control boys (p = 0.04), while weight and body mass index did not differ.
Dietary intervention did not affect pubertal hormonal status. This finding supports the safety of implemented counselling in respect to puberty.
评估饮食咨询对健康青少年青春期发育和激素状态的影响。
我们使用了芬兰图尔库特殊冠状动脉危险因素干预项目的子队列，其中包括 193 名健康男孩（52%）和女孩（48%）。1990-1992 年，护士在图尔库的婴儿诊所招募了参与者，并将他们随机分为干预组和对照组。干预组的儿童在七个月大时开始接受低饱和脂肪和低胆固醇的饮食咨询。参与者在 10 至 19 岁时每年接受一次检查，进行 Tanner 分期、人体测量和生殖激素的连续检测。在女孩中，未分析绝经后激素。
男孩或女孩的青春期激素在干预组和对照组之间没有差异。然而，我们观察到 Tanner 分期和人体测量参数方面青春期进展略有不同。干预组男孩更快地进入 G4（p=0.008）、G5（p=0.008）和 P5（p=0.03）期。干预组男孩比对照组男孩更高（p=0.04），而体重和体重指数没有差异。
饮食干预并未影响青春期的激素状态。这一发现支持了所实施咨询的安全性，不会影响青春期。
