利用倍半萜环化酶的合成潜力生成非天然萜类化合物。
Exploiting the Synthetic Potential of Sesquiterpene Cyclases for Generating Unnatural Terpenoids.
作者信息
Oberhauser Clara, Harms Vanessa, Seidel Katja, Schröder Benjamin, Ekramzadeh Kimia, Beutel Sascha, Winkler Sven, Lauterbach Lukas, Dickschat Jeroen S, Kirschning Andreas
机构信息
Institute of Organic Chemistry and Center of Biomolecular Drug Research (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, 30167, Hannover, Germany.
Institute of Technical Chemistry and Center of Biomolecular Drug Research (BMWZ), Leibniz Universität Hannover, Callinstr. 5, 30167, Hannover, Germany.
出版信息
Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11802-11806. doi: 10.1002/anie.201805526. Epub 2018 Aug 7.
The substrate flexibility of eight purified sesquiterpene cyclases was evaluated using six new heteroatom-modified farnesyl pyrophosphates, and the formation of six new heteroatom-modified macrocyclic and tricyclic sesquiterpenoids is described. GC-O analysis revealed that tricyclic tetrahydrofuran exhibits an ethereal, peppery, and camphor-like olfactoric scent.
使用六种新的杂原子修饰的法呢基焦磷酸酯评估了八种纯化的倍半萜环化酶的底物灵活性，并描述了六种新的杂原子修饰的大环和三环倍半萜类化合物的形成。气相色谱 - 嗅觉分析表明，三环四氢呋喃具有醚类、胡椒味和樟脑样的嗅觉气味。
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