组织异质性对乳腺癌中类固醇受体测定的影响。
Influence of tissue heterogeneity on the determination of steroid receptors in breast cancer.
作者信息
Geyer H, Eberl M, Hornberger B
出版信息
J Cancer Res Clin Oncol. 1985;110(2):141-4. doi: 10.1007/BF00402728.
Biochemical determination of hormone receptors in carcinomas is influenced by the potential heterogeneity of the tissue samples. In order to check this, samples of 16 breast cancers were divided into 6 segments. These segments were alternately examined for their ratio of tumor tissue to connective tissue ("percentage of carcinoma") or for the content of estrogen and progesterone receptors. Only 3 of the tumors were homogeneous, and 9 of the heterogeneous tissues had hormone receptors. The segment with the maximum "percentage of carcinoma" was adjacent to that with the peak value of hormone receptors in all but 1 tissue. The same applied to the minima. The maximum and minimum values of estrogen and progesterone receptors were located within the same segment in all but one tissue sample. The results demonstrated that biochemical assay of hormone receptors is reliable. A reduction of the sample volume does not enhance the precision of the receptor assay, since it increases the possibility of a false negative result.
癌组织中激素受体的生化测定受组织样本潜在异质性的影响。为了对此进行检查，将16例乳腺癌样本分成6个部分。交替检查这些部分的肿瘤组织与结缔组织的比例（“癌百分比”）或雌激素和孕激素受体的含量。只有3个肿瘤是均匀的，9个异质组织有激素受体。除1个组织外，“癌百分比”最高的部分与激素受体峰值的部分相邻。最小值情况相同。除1个组织样本外，雌激素和孕激素受体的最大值和最小值位于同一部分内。结果表明，激素受体的生化测定是可靠的。减少样本量并不会提高受体测定的精度，因为这会增加假阴性结果的可能性。
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