Department of Neurology, Columbia University, New York, New York, USA.
Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA.
Neuroepidemiology. 2018;51(1-2):57-63. doi: 10.1159/000490351. Epub 2018 Jun 28.
White matter hyperintensity volume (WMHV) and subclinical brain infarcts (SBI) are associated with impaired mobility, but less is known about the association of WMHV in specific brain regions. We hypothesized that anterior WMHV would be associated with lower scores on the Short Physical Performance Battery (SPPB), a well-validated mobility scale.
The SPPB was measured a median of 5 years after enrollment into the Northern Manhattan MRI sub study. Volumetric distributions for WMHV in 14 brain regions as a proportion of total cranial volume were determined. Multi-variable linear regression was performed to examine the association of SBI and regional log-WMHV with the SPPB score.
Among 668 participants with SPPB measurements (mean 74 ± 9 years, 37% male and 70% Hispanic), the mean SPPB score was 8.2 ± 2.9. Total (beta = -0.3 per SD, p = 0.001), anterior periventricular (beta = -0.4 per SD, p = 0.001), parietal (beta = -0.2 per SD, p = 0.02) and frontal (beta = -0.3 per SD, p = 0.002) WMHVs were associated with SPPB; other WMHV and SBI were not associated with the SPPB.
WMHV, especially in the anterior -cerebral regions, is associated with a lower SPPB. Prevention of subclinical cerebrovascular disease is a potential target to prevent physical decline in the elderly.
脑白质高信号体积（WMHV）和亚临床脑梗死（SBI）与活动能力受损有关，但人们对特定脑区WMHV 的相关性知之甚少。我们假设，前脑WMHV 与短期身体表现电池（SPPB）评分较低相关，SPPB 是一种经过良好验证的活动能力量表。
在纳入北方曼哈顿 MRI 子研究后，中位数 5 年后测量 SPPB。确定 WMHV 在 14 个脑区的体积分布，占总颅容积的比例。采用多元线性回归分析 SBI 和区域对数 WMHV 与 SPPB 评分的相关性。
在 668 名有 SPPB 测量值的参与者中（平均年龄 74 ± 9 岁，37%为男性，70%为西班牙裔），平均 SPPB 评分为 8.2 ± 2.9。总 WMHV（每标准差β=-0.3，p=0.001）、前脑室周围（每标准差β=-0.4，p=0.001）、顶叶（每标准差β=-0.2，p=0.02）和额叶（每标准差β=-0.3，p=0.002）WMHV 与 SPPB 相关；其他 WMHV 和 SBI 与 SPPB 无关。
WMHV，特别是在前脑区域，与 SPPB 较低相关。预防亚临床脑血管疾病可能是预防老年人身体衰退的目标。
