一种新型光生物调节技术对小鼠β淀粉样肽诱导毒性的神经保护作用：提出阿尔茨海默病治疗方法的新假说。

Neuroprotective effect of a new photobiomodulation technique against Aβ peptide-induced toxicity in mice: Novel hypothesis for therapeutic approach of Alzheimer's disease suggested.

作者信息

Blivet Guillaume, Meunier Johann, Roman Francois J, Touchon Jacques

机构信息

REGEnLIFE, Montpellier, France.

Amylgen, Montferrier-sur-Lez, France.

出版信息

Alzheimers Dement (N Y). 2018 Feb 2;4:54-63. doi: 10.1016/j.trci.2017.12.003. eCollection 2018.

INTRODUCTION

Photobiomodulation was assessed as a novel treatment of Alzheimer's disease (AD) by the use of a new device RGn500 combining photonic and magnetic emissions in a mouse model of AD.

METHODS

Following the injection of amyloid β 25-35 peptide in male Swiss mice, RGn500 was applied once a day for 7 days either on the top of the head or the center of abdomen or both.

RESULTS

RGn500 daily application for 10 min produced a neuroprotective effect on the neurotoxic effects of amyloid β 25-35 peptide injection when this type of photobiomodulation was applied both on the head and on the abdomen. Protection was demonstrated by memory restoration and on the normalization of key markers of AD (amyloid β 1-42, pTau), oxidative stress (lipid peroxidation), apoptosis (Bax/Bcl2) and neuroinflammation.

DISCUSSION

RGn500 displays therapeutic efficacy similar to other pharmacological approaches evaluated in this model of AD.

引言

通过在阿尔茨海默病（AD）小鼠模型中使用一种结合光子和磁发射的新型设备RGn500，对光生物调节作为AD的一种新治疗方法进行了评估。

方法

在雄性瑞士小鼠中注射淀粉样β蛋白25 - 35肽后，RGn500每天应用一次，持续7天，应用部位为头顶或腹部中央或两者皆用。

结果

当这种光生物调节同时应用于头部和腹部时，每天应用RGn500 10分钟可对淀粉样β蛋白25 - 35肽注射的神经毒性作用产生神经保护作用。记忆恢复以及AD关键标志物（淀粉样β蛋白1 - 42、磷酸化tau蛋白）、氧化应激（脂质过氧化）、细胞凋亡（Bax/Bcl2）和神经炎症的正常化证明了这种保护作用。